Quantification of the surgical margin shrinkage in lip cancer: Determining the relation between the surgical and histopathologic margins

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dc.contributor.authorEgemen, Onur
dc.contributor.authorBingöl, Derya
dc.contributor.authorOrman, Çağdaş
dc.contributor.authorSayılgan, Ayşe Tülay
dc.contributor.authorÖzkaya, Özay
dc.contributor.authorAkan, Mithat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:55Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:55Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.descriptionWOS: 000345012000081
dc.descriptionPubMed ID: 25329844
dc.description.abstractLip carcinoma is one of the most common cancers of the head and neck region. Lower lips are more frequently affected. Squamous cell carcinoma accounts for more than 95% of the cases. The aim of treatment is to achieve the highest cure rates with adequate excision with clear surgical margins while leaving the smallest defect sizes behind for reconstruction. Excised tissue is known to shrink when removed, in relation with its retractile properties. In this study, the evaluation of the amount of shrinkage in excised lip cancer specimens and determination of the relation between surgical and histopathologic margins were aimed. The study included 21 consecutive excised lip specimens for the treatment of squamous cell carcinoma of the lip. The volume of the specimen, tumor length, and margin distance measurements were measured and recorded step by step from before surgical excision to histopathologic evaluation. Specimens were evaluated in a standardized fashion by the same pathologist after 48 hours of fixation. For data analysis, Number Cruncher Statistical System 2007 and Power Analysis and Sample Size 2008 Statistical Software (Kaysville, UT) were used. The surgical margins of the excised lip specimen shrink up to 41% to 47.5% from before excision to histopathologic evaluation. The most significant step was the excision step, followed by the formalin fixation step. The histopathologic process itself and the duration of formalin fixation did not result a significant change in surgical margins. The tumor tissue itself did not show a significant shrinkage.
dc.identifier.citationEgemen, O., Bingöl, D., Orman, Ç., Sayılgan, A. T., Özkaya, Ö. ve Akan, M. (2014). Quantification of the surgical margin shrinkage in lip cancer: Determining the relation between the surgical and histopathologic margins. Journal of Craniofacial Surgery, 25(6), 2152-2155. https://dx.doi.org/10.1097/SCS.0000000000001150
dc.identifier.doi10.1097/SCS.0000000000001150
dc.identifier.endpage2155
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage2152
dc.identifier.urihttps://dx.doi.org/10.1097/SCS.0000000000001150
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3072
dc.identifier.volume25
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectLower Lip
dc.subjectSquamous Cell Cancer
dc.subjectSurgical Margin
dc.subjectSpecimen Shrinkage
dc.titleQuantification of the surgical margin shrinkage in lip cancer: Determining the relation between the surgical and histopathologic margins
dc.typeArticle

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