Association between body mass ındex and survival in patients with de novo metastatic non-small cell lung cancer

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dc.contributor.authorÜrün, Muslih
dc.contributor.authorGüner, Gürkan
dc.contributor.authorSezgin, Yasin
dc.contributor.authorSakin, Abdullah
dc.contributor.authorKılıçkap, Saadettin
dc.date.accessioned2025-11-25T17:36:21Z
dc.date.available2025-11-25T17:36:21Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: This retrospective study from a single center included 289 patients diagnosed with advanced non-small cell lung cancer (NSCLC) between 2010 to 2017 and aimed to evaluate the effects of body mass index (BMI) on overall survival. Material/Methods: This retrospective study involved 289 patients diagnosed with metastatic-stage NSCLC at a single institution between January 2010 and December 2017. Patients were categorized into 2 groups based on their BMI at diagnosis: those with a BMI <25 kg/m2 and those with a BMI 325 kg/m2. Univariate and multivariate Cox regression analyses were conducted to identify factors associated with overall survival. Results: A total of 289 patients (241 men, 48 women) were included in the study, with a mean age of 60.1±11.1 years. Among them, 175 patients (60.6%) had a BMI less than 25 kg/m2. Multivariate analysis revealed that BMI, pathological diagnosis, and complete response after first-line treatment were independently associated with survival in patients with lung cancer. Predicted survival time was significantly shorter in the BMI <25 group than in the BMI 325 group (9.3 months vs 13.0 months, P<0.05). Conclusions: The study demonstrated that a higher BMI at the time of diagnosis is associated with improved overall survival in patients with de novo metastatic NSCLC. BMI may serve as an important prognostic factor in this patient population. Future prospective, multi-center studies are necessary to further validate the role of BMI in predicting survival outcomes in NSCLC patients across different treatment modalities.
dc.identifier.citationÜrün, M., Güner, G., Sezgin, Y., Sakin, A. ve Kılıçkap, S. (2024). Association between body mass ındex and survival in patients with de novo metastatic non-small cell lung cancer. Medical Science Monitor, 30. http://dx.doi.org/10.12659/MSM.946751
dc.identifier.doi10.12659/MSM.946751
dc.identifier.issn1643-3750
dc.identifier.pmid39690723
dc.identifier.scopus2-s2.0-85209917576
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.12659/MSM.946751
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13245
dc.identifier.volume30
dc.identifier.wosWOS:001380858100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSakin, Abdullah
dc.institutionauthorid0000-0003-2538-8569
dc.language.isoen
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.subjectBody Mass Index
dc.subjectCarcinoma
dc.subjectNon-Small-Cell Lung
dc.subjectObesity
dc.subjectSurvival
dc.titleAssociation between body mass ındex and survival in patients with de novo metastatic non-small cell lung cancer
dc.typeArticle

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