Supratherapeutic utilization of paracetamol versus ibuprofen among <12-year-old children in primary care in Istanbul

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dc.authorid0000-0002-8511-6349
dc.authorid0000-0001-8984-9673
dc.contributor.authorBayram, Dilara
dc.contributor.authorVızdıklar, Caner
dc.contributor.authorAydın, Volkan
dc.contributor.authorAkıcı, Narin
dc.contributor.authorAtaç, Ömer
dc.contributor.authorAkıcı, Ahmet
dc.date.accessioned2024-06-27T07:35:40Z
dc.date.available2024-06-27T07:35:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractBackground: Paracetamol and ibuprofen are the most preferred analgesics for pain and fever management in children. Prescribing of these drugs in supratherapeutic doses may predispose to their toxicity. We aimed to compare prescribing patterns and potential overdosing of paracetamol and ibuprofen in primary care for <12-year-old children. Methods: We analysed paracetamol- and ibuprofen-containing prescriptions (PCPs, n = 173,575 and ICPs, n = 145,655) of 1- to 11-year-old children, issued by 3:1 systematically sampled primary care physicians (n = 1,431) in Istanbul during 2016. We compared drug use parameters and prescriptions surpassing daily and single-use dose limits for paracetamol and ibuprofen. Results: We identified that 29.9% of PCPs and 20.8% of ICPs were generated for those aged 1-2 years. Concomitant analgesic use was higher in ICPs than in PCPs (15.1% vs. 12.8%). We found that 4.4% of PCPs and 3.1% of ICPs exceeded maximum daily dose limit of paracetamol and ibuprofen, respectively (P < 0.001). This was more common in girls (5.1% and 3.3%, respectively) and at 1 year of age in both groups (9.2% and 8.5%, respectively). Single-use supratherapeutic dosing was encountered in 16.5% of PCPs and 13.2% of ICPs (P < 0.001, pessimistic model) and in 8.6% of PCPs and 10.6% of ICPs (P < 0.001, optimistic model). Conclusions: Paracetamol and ibuprofen were generally used in primary care for similar clinical conditions with subtle differences. However, more pronounced in younger children and girls, potential overdosing seems to be more practiced for paracetamol than ibuprofen both in terms of maximal daily and single-use setting.
dc.identifier.citationBayram, D., Vızdıklar, C., Aydın, V., Akıcı, N., Ataç, Ö. ve Akıcı, A. (2024). Supratherapeutic utilization of paracetamol versus ibuprofen among <12-year-old children in primary care in Istanbul. Family Practice, 41(3), 270-276. http://dx.doi.org/10.1093/fampra/cmad038
dc.identifier.doi10.1093/fampra/cmad038
dc.identifier.endpage276
dc.identifier.issn0263-2136
dc.identifier.issn1460-2229
dc.identifier.issue3
dc.identifier.pmid36964758
dc.identifier.scopus2-s2.0-85196052526
dc.identifier.scopusqualityQ1
dc.identifier.startpage270
dc.identifier.urihttp://dx.doi.org/10.1093/fampra/cmad038
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12656
dc.identifier.volume41
dc.identifier.wos000952227000001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Volkan
dc.institutionauthorAtaç, Ömer
dc.language.isoen
dc.relation.ispartofFamily Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIbuprofen
dc.subjectOverdose
dc.subjectPaediatrics
dc.subjectParacetamol
dc.subjectPreadolescence
dc.subjectSupratherapeutic
dc.titleSupratherapeutic utilization of paracetamol versus ibuprofen among <12-year-old children in primary care in Istanbul
dc.typeArticle

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