Synthesis of novel hybrid lonidamine-coumarin derivatives and their anticancer activities

Basit Öğe Kaydı
dc.contributor.authorŞavluğ İpek, Özgecan
dc.contributor.authorOnur Sucu, Bilgesu
dc.contributor.authorGül, Şeref
dc.contributor.authorYolaçan, Çiğdem
dc.contributor.authorGüzel, Mustafa
dc.date.accessioned2023-02-24T05:43:40Z
dc.date.available2023-02-24T05:43:40Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractIn order to develop drugs against cancer, which is one of the deadliest diseases in the world, hybridizing structures with known anticancer activity can provide a dual activity for the treatment of cancer cases. For this purpose, a series of novel hybrid compounds combining lonidamine and 7-hydroxy-4-methylcoumarin via different linker modifications have been synthesized in this study. The chemical structures of the novel compound were elucidated with 1H and 13C NMR and mass spectrometry (HRMS) methods. All the synthesized compounds were screened for anticancer activity against MCF-7 and A549 cells. Among them, compound 2 appeared to be the most potent compound on MCF-7 lines; and IC50 dose was determined as 33.12 µM. IC50 of Compound 6 was determined as 139.6 µM for A549 cells. Considering anticancer activity studies, compounds 2 and 6 have potential to lead to the development of novel hybrid compounds for cancer therapy. Further studies to identify mechanistic explanations of the bioactivity of these molecules are ongoing and will be reported in due course.
dc.identifier.citationŞavluğ İpek, Ö., Onur Sucu, B., Gül, Ş., Yolaçan, Ç. ve Güzel, M. (2023). Synthesis of novel hybrid lonidamine-coumarin derivatives and their anticancer activities. Journal of Molecular Structure, 1281. https://doi.org/10.1016/j.molstruc.2023.135114
dc.identifier.doi10.1016/j.molstruc.2023.135114
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85148099537
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.135114
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10520
dc.identifier.volume1281
dc.identifier.wos000991495300001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞavluğ İpek, Özgecan
dc.institutionauthorOnur Sucu, Bilgesu
dc.institutionauthorGüzel, Mustafa
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectLonidamine
dc.subjectCoumarin
dc.subjectAnti-Cancer Activity
dc.subjectDrug Discovery
dc.titleSynthesis of novel hybrid lonidamine-coumarin derivatives and their anticancer activities
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Savlug-Ozgecan-2023.pdf
Boyut:
1.78 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu