Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss

Basit Öğe Kaydı
dc.contributor.authorÇallıoğlu, Nihal
dc.contributor.authorGül, Derya Kanza
dc.contributor.authorArslan, İlke Özer
dc.contributor.authorGeyikoğlu, İpek
dc.contributor.authorDemirçivi, Ergül
dc.date.accessioned2025-05-28T17:42:02Z
dc.date.available2025-05-28T17:42:02Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractOBJECTIVES: To uncover the predictive value of systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) on early pregnancy loss. METHODS: A total of 535 individuals were enrolled in this retrospective analysis. The early pregnancy losses (EPL) group included patients between 18-35 years old who experienced EPL. The control group comprised healthy pregnant women who gave birth at ≥37 weeks. RESULTS: The EPL group had significantly lower plateletcrit (p=0.04), platelet distribution width (PDW, p<0.0001), and RDW (p<0.0001) and higher monocyte (p<0.0001) and SIRI (p<0.0001) values than the control group. The hemoglobin, white blood cells, platelet count, neutrophil count, lymphocyte count, mean platelet volume, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII values were not significantly different between the EPL and control groups (p>0.05). The cut-off value for the SIRI that offers the best sensitivity/specificity balance was 1.48 (sensitivity of 63%; specificity of 63%) in the receiver operating characteristics curve. Among the inflammatory parameters for predicting EPL, PDW had highest specificity (84%), and RDW had the highest sensitivity (80%). CONCLUSION: This study provides compelling evidence that various inflammatory pathways may significantly contribute to EPL pathogenesis. Moreover, our findings suggest that SIRI could be a more effective marker than NLR, PLR, MLR, and SII in predicting EPL in an ongoing pregnancy, thereby potentially revolutionizing early pregnancy loss diagnostics.
dc.identifier.citationÇallıoğlu, N., Gül, D. K., Arslan, İ. Ö., Geyikoğlu, İ. ve Demirçivi, E. (2024). Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss. Saudi Medical Journal, 45(8), 808-813. http://dx.doi.org/10.15537/smj.2024.45.8.20240404
dc.identifier.doi10.15537/smj.2024.45.8.20240404
dc.identifier.endpage813
dc.identifier.issn0379-5284
dc.identifier.issn1658-3175
dc.identifier.issue8
dc.identifier.pmid39074885
dc.identifier.scopus2-s2.0-85200101734
dc.identifier.scopusqualityQ3
dc.identifier.startpage808
dc.identifier.urihttp://dx.doi.org/10.15537/smj.2024.45.8.20240404
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12923
dc.identifier.volume45
dc.identifier.wosWOS:001302049400006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGül, Derya Kanza
dc.institutionauthorid0000-0001-8879-9299
dc.language.isoen
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial 4.0 International
dc.subjectEarly Pregnancy Loss
dc.subjectInflammatory Biomarkers
dc.subjectMean Platelet Volume
dc.subjectSystemic Immune-Inflammatory Index
dc.subjectSystemic Inflammatory Response Index
dc.titleInflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Gül-Derya Kanza-2024.pdf
Boyut:
695.37 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu