Neutrophil-lymphocyte ratio and the platelet parameters as biomarkers of atopic dermatitis severity in children

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dc.authorid0000-0003-1333-2648
dc.contributor.authorGayret, Özlem Bostan
dc.contributor.authorErol, Meltem
dc.contributor.authorŞener, Ahmet
dc.contributor.authorNacaroğlu, Hikmet Tekin
dc.date.accessioned2019-12-23T06:54:50Z
dc.date.available2019-12-23T06:54:50Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a specific immune and inflammatory mechanism. This study investigates inflammatory biomarkers and their correlation with disease severity. Objectives: The aim of this study is to determine the relationship between platelet parameters [(mean platelet volume (MPV), platelet distribution width (PDW)], the neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), and AD severity in children. Methods: In this retrospective study, we reviewed patients diagnosed with AD and a healthy control group at the department of pediatrics at Health Sciences in a university-affiliated hospital in Istanbul, Turkey, between January 2015 and December 2016. The study included 79 children with AD and 75 healthy controls. AD severity was graded using the Scoring Atopic Dermatitis (SCORAD) index. Complete blood count was measured, and NLR and PLR were calculated. NLR, PLR, MPV, PDW were compared between AD patients and healthy controls, and the correlations between these indexes and clinical characteristics were analyzed. Results: No significant difference was observed between patients and controls for MPV, NLR, and PLR (P = 0.708, P = 0.340, P = 0.179, respectively). In the AD group, PDW was lower than controls (17.39 +/- 1.45, 18.04 +/- 1.65, P = 0.006). In the severe AD group, MPV was higher (7.62 +/- 1.81, 6.64 +/- 1.16, P = 0.035) and PDW was lower than in the mild AD group (16.52 +/- 1.49, 17.93 +/- 1.44, P = 0.0001). Conclusions: Mean MPV and PDW levels are correlated with atopic dermatitis severity in children.
dc.identifier.citationGayret, O. B., Nacaroğlu, H. T., Erol, M. ve Şener, A. (2019). Neutrophil-lymphocyte ratio and the platelet parameters as biomarkers of atopic dermatitis severity in children. Iranian Red Crescent Medical Journal, 21(7). http://doi.org/10.5812/ircmj.91594
dc.identifier.doi10.5812/ircmj.91594
dc.identifier.issn2074-1804
dc.identifier.issn2074-1812
dc.identifier.issue7
dc.identifier.urihttp://doi.org/10.5812/ircmj.91594
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4591
dc.identifier.volume21
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKowsar Publishing
dc.relation.ispartofIranian Red Crescent Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtopic
dc.subjectBiomarkers
dc.subjectChild
dc.subjectDermatitis
dc.subjectEczema
dc.subjectLymphocytes
dc.subjectNeutrophils
dc.subjectPlatelet
dc.subjectTurkey
dc.titleNeutrophil-lymphocyte ratio and the platelet parameters as biomarkers of atopic dermatitis severity in children
dc.typeArticle

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