Evaluation of sialic acid levels in patients with hydatidiform mole: a preliminary study

Purpose of investigation: This study aims to investigate whether hydatidiform mole (HM) disease with malignant potential is significantly associated with increased sialic acid (SA) levels. Materials and Methods: A total of 114 women were enrolled in this study. Patients were divided into three groups including HM (Group 1, n=34), control group including non-pregnant healthy patients (Group 2, n=42), and another control group including healthy pregnant patients within 12 weeks of gestation (Group 3, n=38). Serum-free SA levels were measured. Results: There was a statistically significant difference in serum-free SA levels among the groups (p < 0.001). Patients with HM had significantly higher levels compared to the control groups. Conclusion: The present study results showed that there was a significant correlation between HM and serum SA level.