Apple cider vinegar modulates serum lipid profile, erythrocyte, kidney, and liver membrane oxidative stress in ovariectomized mice fed high cholesterol

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dc.authorid0000-0001-9403-2844
dc.contributor.authorNaziroğlu, Mustafa
dc.contributor.authorGüler, Mustafa
dc.contributor.authorÖzgül, Cemil
dc.contributor.authorSaydam, Gündüzalp
dc.contributor.authorKüçükayaz, Mustafa
dc.contributor.authorSözbir, Ercan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:37Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:37Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000339895800002
dc.descriptionPubMed ID: 24894721
dc.description.abstractThe purpose of this study was to investigate the potentially beneficial effects of apple cider vinegar (ACV) supplementation on serum triglycerides, total cholesterol, liver and kidney membrane lipid peroxidation, and antioxidant levels in ovariectomized (OVX) mice fed high cholesterol. Four groups of ten female mice were treated as follows: Group I received no treatment and was used as control. Group II was OVX mice. Group III received ACV intragastrically (0.6 % of feed), and group IV was OVX and was treated with ACV as described for group III. The treatment was continued for 28 days, during which the mice were fed a high-cholesterol diet. The lipid peroxidation levels in erythrocyte, liver and kidney, triglycerides, total, and VLDL cholesterol levels in serum were higher in the OVX group than in groups III and IV. The levels of vitamin E in liver, the kidney and erythrocyte glutathione peroxidase (GSH-Px), and erythrocyte-reduced glutathione (GSH) were decreased in group II. The GSH-Px, vitamin C, E, and beta-carotene, and the erythrocyte GSH and GSH-Px values were higher in kidney of groups III and IV, but in liver the vitamin E and beta-carotene concentrations were decreased. In conclusion, ACV induced a protective effect against erythrocyte, kidney, and liver oxidative injury, and lowered the serum lipid levels in mice fed high cholesterol, suggesting that it possesses oxidative stress scavenging effects, inhibits lipid peroxidation, and increases the levels of antioxidant enzymes and vitamin.
dc.description.sponsorshipScientific Turkish Scientific and Technical Research Institute (TUBITAK)en_US
dc.description.sponsorshipMN formulated the present hypothesis and was responsible for writing the report. MG, GS, CO, MK, and ES were responsible for analysis of the data. The authors wish thanks to Dr. Manuel Flores-Arce (Tijuana University, Mexico) for polishing English of the manuscript. The study was partially supported by Scientific Turkish Scientific and Technical Research Institute (TUBITAK-2010).en_US
dc.identifier.citationNaziroğlu, M., Güler, M., Özgül, C., Saydam, G., Küçükayaz, M. ve Sözbir, E. (2014). Apple cider vinegar modulates serum lipid profile, erythrocyte, kidney, and liver membrane oxidative stress in ovariectomized mice fed high cholesterol. The Journal of Membrane Biology, 247(8), 667-673. https://dx.doi.org/10.1007/s00232-014-9685-5
dc.identifier.doi10.1007/s00232-014-9685-5
dc.identifier.endpage673
dc.identifier.issn0022-2631
dc.identifier.issn1432-1424
dc.identifier.issue8
dc.identifier.scopusqualityQ2
dc.identifier.startpage667
dc.identifier.urihttps://dx.doi.org/10.1007/s00232-014-9685-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3201
dc.identifier.volume247
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofThe Journal of Membrane Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOxidative Stress
dc.subjectGlutathione Peroxidase
dc.subjectOvariectomize
dc.subjectHypercholesterolemia
dc.subjectAntioxidant Vitamins
dc.subjectLiver
dc.titleApple cider vinegar modulates serum lipid profile, erythrocyte, kidney, and liver membrane oxidative stress in ovariectomized mice fed high cholesterol
dc.typeArticle

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