Conventional white light imaging-assisted transurethral resection of bladder tumour (TURBT) versus IMAGE1S-assisted TURBT in non-muscle-invasive bladder cancer patients: Trial protocol and 18 months results

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dc.authorid0000-0002-6308-1763
dc.authorid0000-0002-0159-2090
dc.authorid0000-0003-0906-4417
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorMartov, Alexeyb
dc.contributor.authorHurle, Rodolfo
dc.contributor.authorFavre, Gabriel
dc.contributor.authorMamoulakis, Charalampos
dc.contributor.authorCastanheira de Oliveira, Manuel
dc.contributor.authorStenzl, Arnulf
dc.contributor.authorLinares-Espinós, Estefania
dc.contributor.authorTrelles Guzmán, Carlos R.
dc.contributor.authorGravas, Stavros
dc.contributor.authorKnoll, Thomas
dc.contributor.authorBoz, Mustafa Yücel
dc.contributor.authorHerrmann, Thomas
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.date.accessioned2022-12-21T11:22:11Z
dc.date.available2022-12-21T11:22:11Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose White light (WL) is the traditional imaging modality for transurethral resection of bladder tumour (TURBT). IMAGE1S is a likely addition. We compare 18-mo recurrence rates following TURBT using IMAGE1S versus WL guidance. Methods Twelve international centers conducted a single-blinded randomized controlled trial. Patients with primary and recurrent non-muscle-invasive bladder cancer (NMIBC) were randomly assigned 1:1 to TURBT guided by IMAGE1S or WL. Eighteen-month recurrence rates and subanalysis for primary/recurrent and risk groups were planned and compared by chi-square tests and survival analyses. Results 689 patients were randomized for WL-assisted (n = 354) or IMAGE1S-assisted (n = 335) TURBT. Of these, 64.7% had a primary tumor, 35.3% a recurrent tumor, and 4.8%, 69.2% and 26.0% a low-, intermediate-, and high-risk tumor, respectively. Overall, 60 and 65 patients, respectively, completed 18-mo follow-up, with recurrence rates of 31.0% and 25.4%, respectively (p = 0.199). In patients with primary, low-/intermediate-risk tumors, recurrence rates at 18-mo were significantly higher in the WL group compared with the IMAGE1S group (31.9% and 22.3%, respectively: p 0.035). Frequency and severity of adverse events were comparable in both treatment groups. Immediate and adjuvant intravesical instillation therapy did not differ between the groups. Potential limitations included lack of uniformity of surgical resection, central pathology review, and missing data. Conclusion There was not difference in the overall recurrence rates between IMAGE1S and WL assistance 18-mo after TURBT in patients with NMIBC. However, IMAGE1S-assisted TURBT considerably reduced the likelihood of disease recurrence in primary, low/intermediate risk patients. Registration ClinicalTrials.gov Identifier NCT02252549 (30-09-2014).
dc.description.sponsorshipMadrid Regional Government 'Immunothercan'en_US
dc.identifier.citationde la Rosette, J. J. M. C. H., Martov, A., Hurle, R., Favre, G., Mamoulakis, C., Castanheira de Oliveira, M. ... del Pilar Laguna Pes, M. (2022). Conventional white light imaging-assisted transurethral resection of bladder tumour (TURBT) versus IMAGE1S-assisted TURBT in non-muscle-invasive bladder cancer patients: Trial protocol and 18 months results. World Journal of Urology, 40(3), 727-738. https://doi.org/10.1007/s00345-021-03866-4
dc.identifier.doi10.1007/s00345-021-03866-4
dc.identifier.endpage738
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue3
dc.identifier.pmid34741631
dc.identifier.scopus2-s2.0-85118561774
dc.identifier.scopusqualityQ1
dc.identifier.startpage727
dc.identifier.urihttps://doi.org/10.1007/s00345-021-03866-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10155
dc.identifier.volume40
dc.identifier.wos000714991700001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.institutionauthorBoz, Mustafa Yücel
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofWorld Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectImage 1S Imaging
dc.subjectNon-Muscle-Invasive Bladder
dc.subjectTransurethral Resection of Bladder Tumour
dc.subjectTumour Recurrence
dc.subjectWhite Light Imaging
dc.titleConventional white light imaging-assisted transurethral resection of bladder tumour (TURBT) versus IMAGE1S-assisted TURBT in non-muscle-invasive bladder cancer patients: Trial protocol and 18 months results
dc.typeArticle

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