Comparison of assist/control ventilation with and without volume guarantee in term or near-term infants

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dc.authorid0000-0001-8937-4671
dc.contributor.authorBezirganoğlu, Handan
dc.contributor.authorOkur, Nilüfer
dc.contributor.authorBüyüktiryaki, Mehmet
dc.contributor.authorOğuz, Şerife Suna
dc.contributor.authorAlyamaç Dizdar, Evrim
dc.contributor.authorSarı, Fatma Nur
dc.date.accessioned2024-06-04T13:11:19Z
dc.date.available2024-06-04T13:11:19Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives: This study aimed to compare the effects of volume guarantee (VG) combined with assist/control (AC) ventilation to AC alone on hypocarbia episodes and extubation success in infants born at or near term. Methods: In this prospective cohort study, infants >34 weeks of gestation at birth, who were born in our hospital supported by synchronized, time-cycled, pressure limited, assist/control ventilation (AC) or assist-controlled VG mechanical ventilation (AC + VG) were included. After admission, infants received either AC or VG + AC using by Leoni Plus ventilator. The ventilation mode was left to the clinician. In the AC group, peak airway pressure was set clinically. In the VG + AC group, desired tidal volume was set at 5 mL/kg, with the ventilator adjusting peak inspiratory pressure to deliver this volume. The study was completed once the patient extubated. Results: There were 35 patients in each group. Incidence of hypocarbia was lower in the VG + AC compared with AC (%17.1 and 22.8%, respectively) but statistically not significant. Out-of-range partial pressure of carbon dioxide (PCO2) levels were lower in the VG + AC group and it reached borderline statistical significance (p = 0.06). The median extubation time was 70 (42-110) hours in the VG + AC group, 89.5 (48.5-115.5) hours in the AC group, and it did not differ between groups (p = 0.47). Conclusion: We found combining AC and VG ventilation compared with AC ventilation alone yielded similar hypocarbia episodes and extubation time for infants of >34 gestational weeks with borderline significance lower out-of-range PCO2 incidence.
dc.identifier.citationBezirganoğlu, H., Okur, N., Büyüktiryaki, M., Oğuz, Ş. S., Alyamaç Dizdar, E. ve Sarı, F. N. (2024). Comparison of assist/control ventilation with and without volume guarantee in term or near-term infants. American Journal of Perinatology, 41, E174-E179. http://dx.doi.org/10.1055/a-1862-0078
dc.identifier.doi10.1055/a-1862-0078
dc.identifier.endpageE179
dc.identifier.issn0735-1631
dc.identifier.issn1098-8785
dc.identifier.pmid35613941
dc.identifier.scopus2-s2.0-85134467909
dc.identifier.scopusqualityQ2
dc.identifier.startpageE174
dc.identifier.urihttp://dx.doi.org/10.1055/a-1862-0078
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12564
dc.identifier.volume41
dc.identifier.wos000822614300001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBüyüktiryaki, Mehmet
dc.language.isoen
dc.relation.ispartofAmerican Journal of Perinatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAssist Controlled Ventilation
dc.subjectExtubation Success
dc.subjectHypocarbia
dc.subjectTerm Infant
dc.subjectVolume Guarantee
dc.titleComparison of assist/control ventilation with and without volume guarantee in term or near-term infants
dc.typeArticle

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