Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: Effects of nonsurgical periodontal therapy

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dc.authorid0000-0001-7986-7085
dc.contributor.authorKurgan, Şivge
dc.contributor.authorÖnder, Canan
dc.contributor.authorBalcı, Nur
dc.contributor.authorFentoğlu, Özlem
dc.contributor.authorEser, Filiz
dc.contributor.authorBalseven, Müge
dc.contributor.authorSerdar, Muhittin Abdülkadir
dc.contributor.authorTatakis, Dimitris N.
dc.contributor.authorGünhan, Meral
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:27Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:27Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.descriptionWOS: 000399955500030
dc.descriptionPubMed ID: 27781272
dc.description.abstractBackground and ObjectiveThe aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA). Material and MethodsFifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study. Plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing, gingival crevicular fluid t-PA and PAI-2 levels, erythrocyte sedimentation rate, serum C-reactive protein and disease activity score were evaluated at baseline and 3 mo after mechanical nonsurgical periodontal therapy. ResultsAll periodontal clinical parameters were significantly higher in the RA-P and H-P groups compared with the C group (p < 0.001) and decreased significantly after treatment (p < 0.001). Pretreatment t-PA levels were highest in the RA-P group and significantly decreased post-treatment (p = 0.047). Pre- and post-treatment PAI-2 levels were significantly lower in controls compared with both periodontitis groups (p < 0.05). Gingival crevicular fluid volume and the levels of t-PA and PAI-2 were significantly correlated. ConclusionIn patients with periodontitis and RA, nonsurgical periodontal therapy reduced the pretreatment gingival crevicular fluid t-PA levels, which were significantly correlated with gingival crevicular fluid PAI-2 levels. The significantly higher t-PA and PAI-2 gingival crevicular fluid levels in periodontal patients, regardless of systemic status, suggest that the plasminogen activating system plays a role in the disease process of periodontitis.
dc.description.sponsorshipAnkara University Scientific Research Projects Office, Ankara, Turkey [08B3334005]en_US
dc.description.sponsorshipThis study was supported by the Ankara University Scientific Research Projects Office, Ankara, Turkey (08B3334005). The authors declare that they have no conflicts of interest.en_US
dc.identifier.citationKurgan, Ş., Önder, C., Balcı, N., Fentoğlu, Ö., Eser, F., Balseven, M. ... Günhan, M. (2017). Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy. Journal of Periodontal Research, 52(3), 574-581. https://dx.doi.org/10.1111/jre.12425
dc.identifier.doi10.1111/jre.12425
dc.identifier.endpage581
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage574
dc.identifier.urihttps://dx.doi.org/10.1111/jre.12425
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3280
dc.identifier.volume52
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGingival Crevicular Fluid
dc.subjectPeriodontitis
dc.subjectPlasminogen Activator Inhibitor-2
dc.subjectRheumatoid Arthritis
dc.subjectTissue Plasminogen Activator
dc.titleGingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: Effects of nonsurgical periodontal therapy
dc.typeArticle

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