Colistin nephrotoxicity increases with age

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dc.authorid0000-0001-8945-2385
dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorDurdu, Bülent
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorHakyemez, İsmail Necati
dc.contributor.authorÇetin, Birsen
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorGönen, İbak
dc.contributor.authorÖzkan, Ahmet Selim
dc.contributor.authorUzun, Sami
dc.contributor.authorDemirkol, Muhammed Emin
dc.contributor.authorAkbaş, Sedat
dc.contributor.authorKaçmaz, Asiye Bahar
dc.contributor.authorAras, Sükrü
dc.contributor.authorMert, Ali
dc.contributor.authorTabak, Fehmi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:58Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:58Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000342202800002
dc.descriptionPubMed ID: 25073536
dc.description.abstractBackground: Colistin (COL) has become the backbone of the treatment of infections due to extensively drug-resistant (XDR) Gram-negative bacteria. The most common restriction to its use is acute kidney injury (AKI). Methods: We conducted a retrospective cohort study to evaluate risk factors for new-onset AKI in patients receiving COL. The cohort consisted of 198 adults admitted to 9 referral hospitals between January 2010 and October 2012 and treated with intravenous COL for >= 72 h. Patients with no pre-existing kidney dysfunction were compared in terms of risk factors and outcomes of AKI graded according to the RIFLE criteria. Logistic regression analysis was used to identify associated risk factors. Results: A total of 198 patients met the inclusion criteria, of whom 167 had no pre-existing kidney dysfunction; the mean patient age was 58.77 (+/- 18.98) y. Bloodstream infections (34.8%) and ventilator-associated pneumonia (32.3%) were the 2 most common indications for COL use. New-onset AKI developed in 46.1% of the patients, graded as risk (10%), injury (15%), and failure (21%). Patients with high Charlson co-morbidity index (CCI) scores (p = 0.001) and comparatively low initial glomerular filtration rate (GFR) estimations (p < 0.001) were more likely to develop AKI, but older age (p = 0.001; odds ratio 5.199, 95% confidence interval 2.684-10.072) was the major predictor in the multivariate analysis. In-hospital recovery from AKI occurred in 58.1%, within a median of 7 days. Conclusions: COL-induced nephrotoxicity occurred significantly more often in patients older than 60 y of age and was related to low initial GFR estimations and high CCI scores, which were basically determined by age.
dc.identifier.citationBalkan, İ. İ., Doğan, M., Durdu, B., Batırel, A., Hakyemez, İ. N., Çetin, B. ... Tabak, F. (2014). Colistin nephrotoxicity increases with age. Scandinavian Journal of Infectious Diseases, 46(10), 678-685. https://dx.doi.org/10.3109/00365548.2014.926021
dc.identifier.doi10.3109/00365548.2014.926021
dc.identifier.endpage685
dc.identifier.issn0036-5548
dc.identifier.issn1651-1980
dc.identifier.issue10
dc.identifier.scopusqualityN/A
dc.identifier.startpage678
dc.identifier.urihttps://dx.doi.org/10.3109/00365548.2014.926021
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3776
dc.identifier.volume46
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofScandinavian Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColistin
dc.subjectNephrotoxicity
dc.subjectAge
dc.titleColistin nephrotoxicity increases with age
dc.typeArticle

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