Predictive value of serum and follicular fluid chemerin concentrations during assisted reproductive cycles in women with polycystic ovary syndrome

Basit Öğe Kaydı
dc.authorid0000-0003-1985-552X
dc.contributor.authorKabil Kucur, Suna
dc.contributor.authorKürek Eken, Meryem
dc.contributor.authorŞanlı, İlhan
dc.contributor.authorKutlu, Tayfun
dc.contributor.authorBilgiç, Bülent Emre
dc.contributor.authorAltuntaş, Şükriye Leyla
dc.contributor.authorÇevik, Özge
dc.contributor.authorÖzkaya, Enis
dc.date.accessioned2021-10-19T09:47:50Z
dc.date.available2021-10-19T09:47:50Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractAims To evaluate the effect of serum and follicular fluid (ff) Chemerin levels on Assisted Reproductive Technology (ART) outcomes in lean patients with PCOS. Materials and methods The study included 76 infertile reproductive aged women, between 21-35 years who underwent intracytoplasmic sperm injection (ICSI) procedure. Serum and ff Chemerin levels were evaluated. Fertilization and clinical pregnancy rate were compared between the groups. Results Serum (13.32 ng/ml versus 29.82 ng/ml) and ff chemerin (35.90 ng/ml versus 87.60 ng/ml) levels were significantly higher in lean PCOS patients compared to controls (p < .01). Serum (24.5 ng/ml versus 18.4 ng/ml) and ff chemerin (71.7 ng/ml versus 52.8 ng/ml) levels were higher in subjects without clinical pregnancy compared to the subjects with clinical pregnancy (p < .05). A cutoff value of 36.2 ng/ml in the ff chemerin level was found to estimate clinical pregnancy with 83% sensitivity and 52% specificity (Area under the curve 0.66; 95% confidence interval, 0.53-0.79). A cutoff value of 12.7 ng/ml in the serum chemerin level was found to estimate clinical pregnancy with 91% sensitivity and 49% specificity (Area under the curve 0.65; 95% confidence interval, 0.52-0.78). Clinical pregnancy rates were significantly higher in group with lower serum chemerin levels (80.0% versus 30.4%, p < .001). High serum chemerin levels are associated with failure of assisted reproduction [OR:0.1(95% CI, 0.03-0.4, p < .001)]. Conclusions PCOS is associated with higher serum and ff chemerin levels and high serum chemerin level is a risk factor for failed ART cycle.
dc.identifier.citationKabil Kucur, S., Kürek Eken, M., Şanlı, İ., Kutlu, T., Bilgiç, B. E., Altuntaş, Ş. L. ... Özkaya, E. (2021). Predictive value of serum and follicular fluid chemerin concentrations during assisted reproductive cycles in women with polycystic ovary syndrome. Gynecological Endocrinology, 37(9), 814-818. https://dx.doi.org/10.1080/09513590.2021.1937100
dc.identifier.doi10.1080/09513590.2021.1937100
dc.identifier.endpage818
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue9
dc.identifier.scopusqualityQ2
dc.identifier.startpage814
dc.identifier.urihttps://dx.doi.org/10.1080/09513590.2021.1937100
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8467
dc.identifier.volume37
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectChemerin
dc.subjectFollicular Fluid
dc.subjectInfertility
dc.subjectPolycystic Ovary Syndrome
dc.titlePredictive value of serum and follicular fluid chemerin concentrations during assisted reproductive cycles in women with polycystic ovary syndrome
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Altuntas, Sükriye Leyla-2021.pdf
Boyut:
828.53 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu