Effect of cytokine genes in the pathogenesis and on the clinical parameters for the treatment of multiple myeloma

Basit Öğe Kaydı
dc.authorid0000-0002-7129-5024
dc.contributor.authorHaydaroğlu, Handan
dc.contributor.authorOğuzkan Balcı, Sibel
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorGündoğan, Ersin
dc.contributor.authorOkan, Vahap
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorPehlivan, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:22Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:22Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000394527000002
dc.descriptionPubMed ID: 27611810
dc.description.abstractIn this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta-1 (TGF-beta 1), interferon gamma (IFN-gamma), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma (MM) treated with novel therapeutic drugs in Turkish population for the first time except TNF-alpha. We analyzed five cytokine genes in 113 cases with MM and 113 healthy controls. Cytokine genotyping was performed by the polymerase chain reaction-sequence-specific primer method (PCR-SSP). AG genotype associated with high expression in TNF-alpha gene (-308) variant was found to be significantly higher (p = 0.019), and GG genotype associated with low expression in TNF-alpha gene (-308) variant was significantly lower in MM group as compared with controls (p = 0.012). IFN-gamma (+874) variant TT genotype was increased (p = 0.037), and AA genotype was decreased (p = 0.002) in MM group in contrast to controls. IFN-gamma (+874) T allele was higher inMMpatients compared with controls (OR = 1.985, p = 0.000), while A allele was significantly lower (OR = 0.5037, p = 0.0005). Multivariate analysis revealed that factors associated with 5-year overall survival (OS) were only IPI III (RR = 1.630, p = 0.018) and thrombocytopenia (RR = 2.207, Cox p = 0.021), while 5-year event-free survival (EFS) was associated with IPI III (RR = 1.524, p = 0.022), thrombocytopenia (RR = 2.902, p = 0.002), APSCT treatment (RR = 1.729, p = 0.035), and female gender (RR = 0.435, p = 0.002) with negative prognostic values. Our results suggested that TNF-alpha gene (-308) AG genotype and IFN-gamma (+874) TT genotype and T allele may have a role on MM, while other cytokines were not associated with the risk of MM.
dc.identifier.citationHaydaroğlu, H., Oğuzkan B. S., Pehlivan, S., Özdilli, K., Gündoğan, E., Okan, V. … Pehlivan, M. (2017). Effect of cytokine genes in the pathogenesis and on the clinical parameters for the treatment of multiple myeloma. Immunological Investigations, 46(1), 10-21. https://dx.doi.org/10.1080/08820139.2016.1208219
dc.identifier.doi10.1080/08820139.2016.1208219
dc.identifier.endpage21
dc.identifier.issn0882-0139
dc.identifier.issn1532-4311
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage10
dc.identifier.urihttps://dx.doi.org/10.1080/08820139.2016.1208219
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2682
dc.identifier.volume46
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Franis Ltd
dc.relation.ispartofImmunological Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytokine Gene Expression
dc.subjectMultiple Myeloma
dc.subjectPrognostic Factors
dc.titleEffect of cytokine genes in the pathogenesis and on the clinical parameters for the treatment of multiple myeloma
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ozdilli-Kursat-2017.pdf
Boyut:
868.32 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu