Is it better to include necrosis in apparent diffusion coefficient (ADC) measurements? The necrosis/wall ADC ratio to differentiate malignant and benign lecrotic lung lesions: Preliminary results

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dc.contributor.authorKaraman, Adem
dc.contributor.authorDurur Subaşı, Irmak
dc.contributor.authorAlper, Fatih
dc.contributor.authorDurur Karakaya, Afak
dc.contributor.authorSubaşı, Mahmut
dc.contributor.authorAkgün, Metin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:30Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:30Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.descriptionWOS: 000410309300006
dc.descriptionPubMed ID: 28152254
dc.description.abstractPurpose: To determine whether the use of necrosis/wall apparent diffusion coefficient (ADC) ratios in the differentiation of necrotic lung lesions is more reliable than measuring the wall alone. Materials and Methods: In this retrospective study, a total of 76 patients (54 males and 22 females, 71% vs. 29%, with a mean age of 53 +/- 18 years, range, 18-84) were enrolled, 33 of whom had lung carcinoma and 43 had a benign necrotic lung lesion. A 3T scanner was used. The calculation of the necrosis/wall ADC ratio was based on ADC values measured from necrosis and the wall of the lesions by diffusion-weighted imaging (DWI). Statistical analyses were performed with the independent samples t-test and receiver operating characteristic analysis. Intraobserver and interobserver reliability were calculated for ADC values of wall and necrosis. Results: The mean necrosis/wall ADC ratio was 1.67 +/- 0.23 for malignant lesions and 0.75 +/- 0.19 for benign lung lesions (P < 0.001). To estimate malignancy the area under the curve (AUC) values for necrosis ADC, wall ADC, and the necrosis/wall ADC ratio were 0.720, 0.073, and 0.997, respectively. A wall/necrosis ADC ratio cutoff value of 1.12 demonstrated a 100% sensitivity and 98% specificity in the estimation of malignancy. Positive predictive value was 100%, and negative predictive value 98% and diagnostic accuracy 99%. There was a good intraobserver and interobserver reliability for wall and necrosis. Conclusion: The necrosis/wall ADC ratio appears to be a reliable and promising tool for discriminating lung carcinoma from benign necrotic lung lesions than measuring the wall alone.
dc.identifier.citationKaraman, A., Durur Subaşı, I., Alper, F., Durur Karakaya, A., Subaşı, M. ve Akgün, M. (2017). Is it better to include necrosis in apparent diffusion coefficient (ADC) measurements? The necrosis/wall ADC ratio to differentiate malignant and benign lecrotic lung lesions: Preliminary results. Journal of Magnetic Resonance Imaging, 46(4), 1001-1006. https://dx.doi.org/10.1002/jmri.25649
dc.identifier.doi10.1002/jmri.25649
dc.identifier.endpage1006
dc.identifier.issn1053-1807
dc.identifier.issn1522-2586
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage1001
dc.identifier.urihttps://dx.doi.org/10.1002/jmri.25649
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3181
dc.identifier.volume46
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectNecrosis
dc.subjectApparent Diffusion Coefficient (ADC)
dc.subjectMeasurements
dc.subjectNecrosis/Wall
dc.subjectADC Ratio
dc.subjectMalignant and Benign Necrotic Lung Lesions
dc.subjectPreliminary Results
dc.titleIs it better to include necrosis in apparent diffusion coefficient (ADC) measurements? The necrosis/wall ADC ratio to differentiate malignant and benign lecrotic lung lesions: Preliminary results
dc.typeArticle

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