New generation oral anticoagulant apixaban enhances embryo implantation by increasing integrin ?3 expression in rats: A pilot study

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dc.authorid0000-0003-0128-6947
dc.contributor.authorYıldırım Köpük, Şule
dc.contributor.authorÖzer, Nida
dc.contributor.authorÇekmez, Yasemin
dc.contributor.authorÇakır, Aslı
dc.contributor.authorGürkan, Kıran
dc.date.accessioned2022-10-25T13:12:20Z
dc.date.available2022-10-25T13:12:20Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObjective: The first aim of this study was to investigate the effect of apixaban on endometrial receptivity via immunohistochemical investigation of integrin ?3 expression in pregnant rats. The second aim was to compare the endometrial effects of both subcutaneous and oral anticoagulant drugs in terms of integrin ?3 expressions. Methods: A total of 24 rats were selected for this study and divided into three equal groups as control, enoxaparin and apixaban groups. Subcutaneous enoxaparin and oral apixaban were applied for 15 days starting on the first day of pregnancy. On the 15th day of pregnancy, all rats were killed by cervical dislocation, and uterine horns, including pregnancy materials, were investigated for pregnancy success and endometrial receptivity by using immunohistochemical integrin ?3 staining. Results: Living, viable fetuses were higher in the apixaban group compared to the control group (p=0.037). Intensity and universality of immunohistochemical staining of integrin ?3 for endometrial stroma were detected statistically higher in the apixaban group than the other groups. (p=0.009 for intensity, p=0.014 for universality). Endometrial epithelial and myometrial integrin ?3 expression were detected to be identical between the groups (p=0.3). Conclusions: Apixaban enhances endometrial receptivity via increasing integrin ?3 expression in rats. This result can lead to further studies to be done in the future.
dc.identifier.citationYıldırım Köpük, Ş., Özer, N., Çekmez, Y., Çakır, A. ve Gürkan, K. (2022). New generation oral anticoagulant apixaban enhances embryo implantation by increasing integrin ?3 expression in rats: A pilot study. Jornal Brasileiro de Reproducao Assistida, 26(4), 589-593. https://doi.org/10.5935/1518-0557.20210122
dc.identifier.doi10.5935/1518-0557.20210122
dc.identifier.endpage593
dc.identifier.issn1517-5693
dc.identifier.issue4
dc.identifier.pmid35322952
dc.identifier.scopus2-s2.0-85139712468
dc.identifier.scopusqualityQ2
dc.identifier.startpage589
dc.identifier.urihttps://doi.org/10.5935/1518-0557.20210122
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9878
dc.identifier.volume26
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇakır, Aslı
dc.language.isoen
dc.publisherSBRA - Associação Brasileira de Reprodução Assistida (Brazilian Society of Assisted Reproduction)
dc.relation.ispartofJornal Brasileiro de Reproducao Assistidaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnticoagulant
dc.subjectApixaban
dc.subjectEndometrial Receptivity
dc.subjectImplantation
dc.subjectIntegrin ?3
dc.titleNew generation oral anticoagulant apixaban enhances embryo implantation by increasing integrin ?3 expression in rats: A pilot study
dc.typeArticle

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