Dual effects of testosterone in Behcet's disease: Implications for a role in disease pathogenesis

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dc.authorid0000-0002-9927-3644
dc.contributor.authorYavuz Kurhan, Şule
dc.contributor.authorAkdeniz, Tuba Fatma
dc.contributor.authorHancer, Veysel Sabri
dc.contributor.authorBıçakcıgil, Müge
dc.contributor.authorCan, Meryem
dc.contributor.authorYanıkkaya Demirel, Gülderen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:05Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000383111500003
dc.descriptionPubMed ID: 27467286
dc.description.abstractBehcet's disease (BD) exhibits more severe disease course and higher mortality among male patients. However, underlying mechanisms of gender differences in clinical manifestations and disease severity are unclear. The aim of this study was to determine whether testosterone (T) has any role on BD pathogenesis. We studied peripheral blood mononuclear cells (PBMC) and neutrophils of BD patients and controls. Functional assay of neutrophils, cytokine measurements of culture supernatants and gene expressions on both cells were analyzed before and after T incubation. Neutrophils were significantly activated after incubation with T in only BD patients. Incubation with T caused significantly elevated interleukin (IL)-12 and IL-2 in BD. Gene expression of IL-10 was significantly downregulated after incubation with T in BD, especially in male patients. The same difference was observed in IL-10 levels in culture supernatant after T. Baseline TLR4 expression was significantly higher in BD patients compared to healthy donors (HC). Toll-like receptor (TLR) 4 expression on PBMC was significantly elevated in female BD patients. ERAP1 expressions of all patients and controls were decreased under the T effect but it differed significantly between BD vs HC. Baseline IL23R expression was higher in BD males compared with females but the difference disappeared after T. When BD patients were analyzed separately, baseline C-C motif chemokine receptor1 (CCR1), STAT4, TLR4 and KLRC4 expressions were lower in males. Despite immunosuppressive behavior in healthy subjects, T causes neutrophil hyperactivation and TH1 type immune alterations in BD patients. Our results suggest that T may have a role in BD pathogenesis by altering the expression level of IL-10, TLR4, ERAP1, CCR1.
dc.identifier.citationYavuz Kurhan, Ş., Akdeniz, T. F., Hancer, V. S., Bıçakcıgil, M., Can, M. ve Yanıkkaya Demirel, G. (2016). Dual effects of testosterone in Behcet's disease: Implications for a role in disease pathogenesis. Genes And Immunity, 17(6), 335-341. https://dx.doi.org/10.1038/gene.2016.28
dc.identifier.doi10.1038/gene.2016.28
dc.identifier.endpage341
dc.identifier.issn1466-4879
dc.identifier.issn1476-5470
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage335
dc.identifier.urihttps://dx.doi.org/10.1038/gene.2016.28
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2561
dc.identifier.volume17
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofGenes And Immunityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDual Effects
dc.subjectBehcet's Disease
dc.subjectPathogenesis
dc.titleDual effects of testosterone in Behcet's disease: Implications for a role in disease pathogenesis
dc.typeArticle

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