Is the necrosis/wall ADC ratio useful for the differentiation of benign and malignant breast lesions?

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dc.authorid0000-0002-6745-0159
dc.contributor.authorDurur Subaşı, Irmak
dc.contributor.authorDurur Karakaya, Afak
dc.contributor.authorKaraman, Adem
dc.contributor.authorŞeker, Mehmet
dc.contributor.authorDemirci, Elif
dc.contributor.authorAlper, Fatih
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:56Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:56Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.descriptionWOS: 000402802300017
dc.descriptionPubMed ID: 28339285
dc.description.abstractObjective: To determine whether the necrosis/wall apparent diffusion coefficient (ADC) ratio is useful for the malignant-benign differentiation of necrotic breast lesions. Methods: Breast MRI was performed using a 3-T system. In this retrospective study, calculation of the necrosis/wall ADC ratio was based on ADC values measured from the necrosis and from the wall of malignant and benign breast lesions by diffusion-weighted imaging (DWI). By synchronizing post-contrast T1 weighted images, the separate parts of wall and necrosis were maintained. All the diagnoses were pathologically confirmed. Statistical analyses were conducted using an independent sample t-test and receiver operating characteristic analysis. The intraclass and interclass correlations were evaluated. Results: A total of 66 female patients were enrolled, 38 of whom had necrotic breast carcinomas and 28 of whom had breast abscesses. The ADC values were obtained from both the wall and necrosis. The mean necrosis/wall ADC ratio (6 standard deviation) was 1.6160.51 in carcinomas, and it was 0.6560.33 in abscesses. The area under the curve values for necrosis ADC, wall ADC and the necrosis/wall ADC ratio were 0.680, 0.068 and 0.942, respectively. A wall/necrosis ADC ratio cut-off value of 1.18 demonstrated a sensitivity of 97%, specificity of 93%, a positive-predictive value of 95%, a negative-predictive value of 96% and an accuracy of 95% in determining the malignant nature of necrotic breast lesions. There was a good intra- and interclass reliability for the ADC values of both necrosis and wall. Conclusion: The necrosis/wall ADC ratio appears to be a reliable and promising tool for discriminating breast carcinomas from abscesses using DWI. Advances in knowledge: ADC values of the necrosis obtained by DWI are valuable for malignant-benign differentiation in necrotic breast lesions. The necrosis/wall ADC ratio appears to be a reliable and promising tool in the breast imaging field.
dc.identifier.citationDurur Subaşı, I., Durur Karakaya, A., Karaman, A., Şeker, M., Demirci, E. ve Alper, F. (2017). Is the necrosis/wall ADC ratio useful for the differentiation of benign and malignant breast lesions? British Journal of Radiology, 90(1073). https://dx.doi.org/10.1259/bjr.20160803
dc.identifier.doi10.1259/bjr.20160803
dc.identifier.issn0007-1285
dc.identifier.issn1748-880X
dc.identifier.issue1073
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1259/bjr.20160803
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2111
dc.identifier.volume90
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBritish Institute of Radiology
dc.relation.ispartofBritish Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectADC Ratio
dc.subjectMalignant Breast Lesions
dc.subjectDifferentiation of Benign
dc.titleIs the necrosis/wall ADC ratio useful for the differentiation of benign and malignant breast lesions?
dc.typeArticle

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