Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei

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dc.authorid0000-0003-2776-5807
dc.contributor.authorEdsall, Connor
dc.contributor.authorKhan, Zerin Mahzabin
dc.contributor.authorMancia, Lauren
dc.contributor.authorHall, Sarah
dc.contributor.authorMustafa, Waleed
dc.contributor.authorJohnsen, Eric
dc.contributor.authorKlibanov, Alexander L.
dc.contributor.authorYĆ¼ksel Durmaz, Yasemin
dc.contributor.authorVlaisavljevich, Eli
dc.date.accessioned2021-03-12T11:35:29Z
dc.date.available2021-03-12T11:35:29Z
dc.date.issued2021
dc.departmentÄ°stanbul Medipol Ɯniversitesi, MĆ¼hendislik ve Doğa Bilimleri FakĆ¼ltesi, Biyomedikal MĆ¼hendisliği BƶlĆ¼mĆ¼
dc.departmentÄ°stanbul Medipol Ɯniversitesi, RektƶrlĆ¼k, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractThe study described here examined the effects of cavitation nuclei characteristics on histotripsy. Highspeed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic and artificial cavitation nuclei (gas-filled microbubbles, fluid-filled nanocones). Results showed a significant decrease in the cavitation threshold for microbubbles and nanocones compared with intrinsic-nuclei controls, with predictable and well-defined bubble clouds generated in all cases. Red blood cell experiments showed complete ablations for intrinsic and nanocone phantoms, but only partial ablation in microbubble phantoms. Results also revealed a lower rate of ablation in artificial-nuclei phantoms because of reduced bubble expansion (and corresponding decreases in stress and strain). Overall, this study demonstrates the potential of using artificial nuclei to reduce the histotripsy cavitation threshold while highlighting differences in the bubble cloud behavior and ablation capacity that need to be considered in the future development of these approaches.
dc.description.sponsorshipNational Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (NIH) ; Virginia Tech Institute for Critical Technology and Applied Science (ICTAS) ; United States Department of Health & Human Services National Institutes of Health (NIH) - USA ; Turkish Academy of Sciences through its Outstanding Young Scientist Award Program (TUBA-GEBIP) ; Office of Naval Researchen_US
dc.identifier.citationEdsall, C., Khan, Z. M., Mancia, L., Hall, S., Mustafa, W., Johnsen, E. ... Vlaisavljevich, E. (2021). Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei. Ultrasound in Medicine and Biology, 47(3), 620-639. https://dx.doi.org/10.1016/j.ultrasmedbio.2020.10.020
dc.identifier.doi10.1016/j.ultrasmedbio.2020.10.020
dc.identifier.endpage639
dc.identifier.issn0301-5629
dc.identifier.issn1879-291X
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage620
dc.identifier.urihttps://dx.doi.org/10.1016/j.ultrasmedbio.2020.10.020
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6610
dc.identifier.volume47
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUltrasound in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Ɩğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/118 Z324
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHistotripsy
dc.subjectMicrotripsy
dc.subjectNanoparticles
dc.subjectMicrobubbles
dc.subjectCavitation
dc.subjectAblation
dc.titleBubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei
dc.typeArticle

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