Stereotactic body radioablation therapy as an immediate and early term antiarrhythmic palliative therapeutic choice in patients with refractory ventricular tachycardia

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dc.contributor.authorAras, Dursun
dc.contributor.authorÇetin, Elif Hande Özcan
dc.contributor.authorÖztürk, Hüseyin Furkan
dc.contributor.authorÖzdemir, Elif
dc.contributor.authorKara, Meryem
dc.contributor.authorEkizler, Firdevs Ayşenur
dc.contributor.authorÖzeke, Özcan
dc.contributor.authorÖzcan, Fırat
dc.contributor.authorKorkmaz, Ahmet
dc.contributor.authorKervan, Ümit
dc.contributor.authorTurhan, Nesrin
dc.contributor.authorCoşkun, Nazım
dc.contributor.authorTopaloğlu, Serkan
dc.date.accessioned2023-09-26T08:46:07Z
dc.date.available2023-09-26T08:46:07Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: Stereotactic body radioablation therapy (SBRT) has recently been introduced with the ability to provide ablative energy noninvasively to arrhythmogenic substrate while reducing damage to normal cardiac tissue nearby and minimizing patients’ procedural risk. There is still debate regarding whether SBRT has a predominant effect in the early or late period after the procedure. We sought to assess the time course of SBRT’s efficacy as well as the value of using a blanking period following a SBRT session. Methods: Eight patients (mean age 58 ± 14 years) underwent eight SBRT sessions for refractory ventricular tachycardia (VT). SBRT was given using a linear accelerator device with a total dose of 25 Gy to the targeted area. Results: During a median follow-up of 8 months, all patients demonstrated VT recurrences; however, implantable cardioverter-defibrillator (ICD) and anti-tachycardia pacing therapies were significantly reduced with SBRT (8.46 to 0.83/per month, p = 0.047; 18.50 to 3.29/per month, p = 0.036, respectively). While analyzing the temporal SBRT outcomes, the 2 weeks to 3 months period demonstrated the most favorable outcomes. After 6 months, one patient was ICD therapy-free and the remaining patients demonstrated VT episodes. Conclusions: Our findings showed that the SBRT was associated with a marked reduction in the burden of VT and ICD interventions especially during first 3 months. Although SBRT does not seem to succeed complete termination of VT in long-term period, our findings support the strategy that SBRT can be utilized for immediate antiarrhythmic palliation in critically ill patients with otherwise untreatable refractory VT and electrical storm.
dc.identifier.citationAras, D., Çetin, E. H. Ö., Öztürk, H. F., Özdemir, E., Kara, M., Ekizler, F. A. ... Topaloğlu, S. (2023). Stereotactic body radioablation therapy as an immediate and early term antiarrhythmic palliative therapeutic choice in patients with refractory ventricular tachycardia. Journal of Interventional Cardiac Electrophysiology, 66(1), 135-143. https://doi.org/10.1007/s10840-022-01352-4
dc.identifier.doi10.1007/s10840-022-01352-4
dc.identifier.endpage143
dc.identifier.issn1383-875X
dc.identifier.issn1572-8595
dc.identifier.issue1
dc.identifier.pmid36040658
dc.identifier.scopus2-s2.0-85136939634
dc.identifier.scopusqualityQ2
dc.identifier.startpage135
dc.identifier.urihttps://doi.org/10.1007/s10840-022-01352-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11498
dc.identifier.volume66
dc.identifier.wos000847605200001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAras, Dursun
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Interventional Cardiac Electrophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStereotactic Body Radioablation Therapy
dc.subjectVentricular Tachycardia
dc.subjectICD Therapy
dc.titleStereotactic body radioablation therapy as an immediate and early term antiarrhythmic palliative therapeutic choice in patients with refractory ventricular tachycardia
dc.typeArticle

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