GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy

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dc.authorid0000-0002-6895-8560
dc.contributor.authorErkoç, Reha
dc.contributor.authorÇıkrıkçıoğlu, Mehmet Ali
dc.contributor.authorAintab, Emre
dc.contributor.authorErek-Toprak, Aybala
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorGök, Özlem
dc.contributor.authorYasin Çetin, Ayşe İrem
dc.contributor.authorZorlu, Mehmet
dc.contributor.authorKıskaç, Muharrem
dc.contributor.authorÇakırca, Mustafa
dc.contributor.authorErkal, Sena Nur
dc.contributor.authorİsen, Hayati Can
dc.contributor.authorKaratoprak, Cumali
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:50Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.descriptionWOS: 000361338400021
dc.descriptionPubMed ID: 25869052
dc.description.abstractBackground - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. It was shown that GAS6 intron 8 c.834+7G>A polymorphism is protective against type 2 diabetes mellitus, and AA genotype is associated with higher blood levels of GAS6 protein. Our aim is to investigate whether this polymorphism is a risk factor for diabetic nephropathy in type 2 diabetes mellitus. Method: Eighty-seven patients with diabetic nephropathy were compared with 66 non-diabetic controls in terms of GAS6 intron 8 c.834+7G>A polymorphism. Patients with history of stroke, ischemic heart disease were excluded. Each patient was examined by the ophthalmologist to determine diabetic retinopathy. Results: Frequency of GG, GA and AA genotypes are similar in diabetic nephropathy and control groups according to GAS6 intron 8 c.834+7G>A polymorphism (p = 0.837). Rate of diabetic retinopathy was 54.02%. In the subgroup analysis, GA genotype was significantly more frequent than GG genotype in patients with diabetic retinopathy when compared to without diabetic retinopathy (p = 0.010). Conclusion: In our study, GAS6 intron 8 c.834+7G>A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
dc.identifier.citationErkoç, R., Çıkrıkçıoğlu, M. A., Aintab, E., Erek-Toprak, A., Kılıç, Ü., Gök, Ö. ... Karatoprak, C. (2015). GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy. Renal Failure, 37(5), 866-870. https://dx.doi.org/10.3109/0886022X.2015.1034606
dc.identifier.doi10.3109/0886022X.2015.1034606
dc.identifier.endpage870
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage866
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2015.1034606
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3747
dc.identifier.volume37
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlbuminuria
dc.subjectDiabetes Mellitus
dc.subjectDiabetic Nephropathy
dc.subjectGAS6 Gene
dc.subjectPolymorphism
dc.titleGAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy
dc.typeArticle

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