Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients

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dc.authorid0000-0001-6639-2797
dc.authorid0000-0002-6952-3470
dc.contributor.authorGünlüoğlu, Gülşah
dc.contributor.authorSeyhan, Ekrem Cengiz
dc.contributor.authorKazancıoğlu, Rumeyza
dc.contributor.authorGünlüoğlu, Zeki
dc.contributor.authorŞimşek Veske, Nurdan
dc.contributor.authorErtan Yazar, Esra
dc.contributor.authorAltın, Sedat
dc.date.accessioned2022-04-11T07:49:50Z
dc.date.available2022-04-11T07:49:50Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective Patients undergoing haemodialysis for chronic renal failure-hemodialysis (CRF-HD) are at risk of latent tuberculosis infection (LTBI). The effectiveness of using blood IP-10 production capacity to diagnose LTBI in CRF-HD patients was analysed. Methods The study enrolled 50 CRF-HD patients. Interferon-gamma release assay (IGRA) was done using QuantiFERON-TB Gold In Tube (QFG-IT) system. Blood IP-10 production capacity was measured using the QFG-IT system tubes. Tuberculin skin testing (TST) was performed on the same day and the test results were compared. Results TST turned out to be positive in 36.4% of the patients and QFG-IT in 54% of them. After stimulation with specific tuberculosis antigens, blood IP-10 levels increased noticeably. The antigen-stimulated blood IP-10 level was significantly higher in patients who were either TST or QFG-IT positive than in patients whose tests were negative (p=0.0001). Using 4.02 pg/mL as the threshold for stimulated blood log-transformed IP-10 level, good agreement was observed between IP-10 and QFG-IT results (kappa=1). Conclusion Blood IP-10 level, which can be measured simply, provides results equivalent to IGRAs for the diagnosis of LTBI in CRF-HD patients.
dc.identifier.citationGünlüoğlu, G., Seyhan, E. C., Kazancıoğlu, R., Günlüoğlu, Z., Şimşek Veske, N., Ertan Yazar, E. ... Altın, S. (2015). Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients. 54(5), 465-472. https://doi.org/10.2169/internalmedicine.54.3245
dc.identifier.doi10.2169/internalmedicine.54.3245
dc.identifier.endpage472
dc.identifier.issn0918-2918
dc.identifier.issn1349-7235
dc.identifier.issue5
dc.identifier.pmidPMID: 25758071
dc.identifier.scopusqualityQ3
dc.identifier.startpage465
dc.identifier.urihttps://doi.org/10.2169/internalmedicine.54.3245
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9281
dc.identifier.volume54
dc.identifier.wosWOS:000350745700005en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSeyhan, Ekrem Cengiz
dc.institutionauthorGünlüoğlu, Zeki
dc.language.isoen
dc.publisherJ-Stage
dc.relation.ispartofInternal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLatent Tuberculosis Infection
dc.subjectChronic Renal Failure
dc.subjectIP-10
dc.subjectIGRA
dc.subjectTST
dc.titleDiagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients
dc.typeArticle

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