Factor XIII Val34Leu polymorphism in patients with cardiac syndrome X

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dc.authorid0000-0002-4607-5724
dc.authorid0000-0002-4281-0867
dc.contributor.authorBabür Güler, Gamze
dc.contributor.authorBatgerel, Ulaankhuu
dc.contributor.authorGüler, Ekrem
dc.contributor.authorKaraca, Oğuz
dc.contributor.authorGeçmen, Çetin
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorZencirkıran Ağuş, Hicaz
dc.contributor.authorEsen, Ali Metin
dc.contributor.authorTürkmen, Mehmet Muhsin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:00Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:00Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000334851000002
dc.descriptionPubMed ID: 23677728
dc.description.abstractBackground: The aim of the study was to examine the frequency of factor XIII polymorphism among patients with cardiac syndrome X (CSX). Methods: This study was designed as a cross-sectional and observational study. Forty-eight female patients with CSX and 36 controls matched by age, gender, diabetes, and hypertension were studied. CSX was defined as typical chest pain during rest or effort, abnormal test result for exercise ECG, and presence of angiographically normal epicardial coronary arteries after ruling out inducible spasm. Factor XIII gene polymorphism was investigated by using CVD Strip Assay (ViennaLab Diagnostic GmbH) commercial kit. Results: The frequency of factor XIII (Val/Leu + Leu/Leu) mutation was significantly higher in patients with CSX (43%) than in controls (19%) (p = 0.02). Frequency of the Leu allele was significantly higher in the patient group (23.5% vs. 11.1%, p = 0.04). Factor XIII (Val//Leu + Leu/Leu) mutation (p = 0.01, OR = 3.42; 95% CI 1.22-9.58) and smoking (p = 0.04, OR = 3.33, 95% CI 1.05-10.58) were identified as independent predictors of the disease in multivariate regression analysis. Conclusions: This study indicates that there is an evidence for association between factor XIII Val34Leu polymorphism and CSX.
dc.identifier.citationBabür Güler, G., Batgerel, U., Güler, E., Karaca, O., Geçmen, Ç., Güneş, H. M. ... Türkmen, M. M. (2014). Factor XIII Val34Leu polymorphism in patients with cardiac syndrome X. Cardiology Journal, 21(1), 6-10. https://dx.doi.org/10.5603/CJ.a2013.0046
dc.identifier.doi10.5603/CJ.a2013.0046
dc.identifier.endpage10
dc.identifier.issn1897-5593
dc.identifier.issn1898-018X
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage6
dc.identifier.urihttps://dx.doi.org/10.5603/CJ.a2013.0046
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2123
dc.identifier.volume21
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medica Journals
dc.relation.ispartofCardiology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiac Syndrome X
dc.subjectFactor XIII Polymorphism
dc.titleFactor XIII Val34Leu polymorphism in patients with cardiac syndrome X
dc.typeArticle

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