The predictive importance of body mass index on response to neoadjuvant chemotherapy in patients with breast cancer

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dc.contributor.authorEmirzeoğlu, Levent
dc.contributor.authorArıcı, Serdar
dc.contributor.authorŞahin, Ahmet Bilgehan
dc.contributor.authorOcak, Birol
dc.contributor.authorAk, Naziye
dc.contributor.authorAy, Seval
dc.contributor.authorMammadov, Elkhan
dc.contributor.authorTurna, Hande
dc.contributor.authorBilici, Ahmet
dc.date.accessioned2023-03-10T09:12:08Z
dc.date.available2023-03-10T09:12:08Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose: The aim of the study was to investigate the effects of body mass index (BMI) on the response to neoadjuvant chemotherapy (NACT) in Turkish patients with local and locally advanced breast cancer. Methods: The pathological responses for the breast and axilla were assessed according to the Miller-Payne grading (MPG) system. Tumors were grouped into molecular phenotypes and classified as response rates according to the MPG system after the completion of NACT. A 90% or greater reduction in tumor cellularity was considered a good response to treatment. Additionally, patients were grouped according to BMI into <25 (group A) and ?25 (group B). Results: In total, 647 Turkish women with breast cancer were included in the study. In the univariate analysis, age, menopause status, tumor diameter, stage, histological grade, Ki-67, estrogen receptor (ER) status, progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) status, and BMI were assessed to determine which of these factors were associated with a ?90% response rate. Stage, HER2 positivity, triple-negative breast cancer (TNBC; ER-negative, PR-negative, and HER2-negative breast cancer), grade, Ki-67 levels, and BMI were found to be the statistically significant factors for a ?90% response rate. In the multivariate analysis, grade III disease, HER2 positivity, and TNBC were found to be the factors associated with a high pathological response. Meanwhile, hormone receptor (HR) positivity and a higher BMI were associated with a decreased pathological response in patients receiving NACT for breast cancer. Conclusion: Our results show that a high BMI and HR positivity are associated with a poor response to NACT in Turkish patients with breast cancer. The findings presented in this study may guide novel studies to examine the NACT response in obese patients with and without insulin resistance.
dc.identifier.citationEmirzeoğlu, L., Arıcı, S., Şahin, A. B., Ocak, B., Ak, N., Ay, S. ... Bilici, A. (2023). The predictive importance of body mass index on response to neoadjuvant chemotherapy in patients with breast cancer. Breast Care, 18(1), 42-48. https://dx.doi.org/10.1159/000526732
dc.identifier.doi10.1159/000526732
dc.identifier.endpage48
dc.identifier.issn1661-3791
dc.identifier.issn1661-3805
dc.identifier.issue1
dc.identifier.pmid36876171
dc.identifier.scopus2-s2.0-85149126642
dc.identifier.scopusqualityQ1
dc.identifier.startpage42
dc.identifier.urihttps://dx.doi.org/10.1159/000526732
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10606
dc.identifier.volume18
dc.identifier.wos000855007700001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMammadov, Elkhan
dc.institutionauthorBilici, Ahmet
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofBreast Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBody Mass Index
dc.subjectBreast Neoplasms
dc.subjectNeoadjuvant Therapy
dc.subjectPathological Response
dc.titleThe predictive importance of body mass index on response to neoadjuvant chemotherapy in patients with breast cancer
dc.typeArticle

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