Preliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson's disease

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dc.authorid0000-0003-4292-5717
dc.authorid0000-0001-7566-1063
dc.authorid0000-0002-9704-6173
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorSarıcaoğlu, Mevhibe
dc.contributor.authorToprak, Güven
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2020-05-08T08:12:50Z
dc.date.available2020-05-08T08:12:50Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Fizyoterapi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.description.abstractIt has been already shown that the motor symptoms of the Parkinson's Disease (PD) have been improved with high frequency rTMS although there is no consensus on the most suitable target brain localization for a maximal therapeutic efficacy. Here, we aimed to compare the therapeutic effect of high frequency (5Hz) rTMS stimulation on primary motor cortex (M1) and pre-supplementary (pre SMA) regions in patients with PD who were still on pharmacological treatment. The study included right-hand dominant16 patients with PD (5 females, 11 males) with demographically and clinically similar characteristics which were randomly assigned to group 1 (n=8) and group 2 (n=8) and received left M1 and the left pre-SMA rTMS procedure, respectively. Total and sequential motor scores of the Unified Parkinson's Disease Rating Scale (UPDRSmotor) were applied to all patients at the baseline and the patients were re-evaluated under the same clinical conditions one week after the end of the sessions. Comparisons of the UPDRS-motor scores between two groups yielded significant improvements after the rTMS on pre-SMA compared to M1 (M1 p=0.14; pre-SMA p=0.01). which were especially significant for the bradykinesia (p=0.04) and axial score related items (p=0.01). This is the first study that shows the effect of rTMS on pre-SMA and it appears to be a promising option in the treatment of PD.
dc.identifier.citationHanoğlu, L., Sarıcaoğlu, M., Toprak, G., Helvacı Yılmaz, N. ve Yuluğ, B. (2020). Preliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson's disease. Neuroscience Letters, 724. https://doi.org/10.1016/j.neulet.2020.134837
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2020.134837
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5214
dc.identifier.volume724
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHigh Frequency Rtms
dc.subjectM1 Stimulation
dc.subjectParkinson's Disease
dc.subjectPre-SMA Stimulation
dc.titlePreliminary findings on the role of high-frequency (5Hz) rTMS stimulation on M1 and pre-SMA regions in Parkinson's disease
dc.typeArticle

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