Correlation of caveolin-1 expression with prognosis in patients with gastric cancer after gastrectomy

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dc.contributor.authorŞeker, Mesut
dc.contributor.authorAydın, Dinçer
dc.contributor.authorBilici, Ahmet
dc.contributor.authorYavuzer, Dilek
dc.contributor.authorÖzgün Geçer, Melin
dc.contributor.authorÖzçelik, Melike
dc.contributor.authorAydın, Özhan
dc.contributor.authorAliustaoğlu, Mehmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:14Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:14Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000398884100003
dc.descriptionPubMed ID: 28365694
dc.description.abstractBackground: Upregulation of caveolin-1 (Cav-1) expression is correlated with histopathological grade and poor prognosis in several human cancers. However, in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear. Methods: The prognostic importance of Cav-1 expression was retrospectively analyzed by immunohistochemistry in 148 patients with gastric cancer who had undergone radical gastrectomy. Results: Cav-1 expression was positive in 23 (15.5%) patients and negative in 125 (84.5%) patients. Tumor location, tumor grade, lymph node involvement, pT stage, pTNM stage, and the presence of recurrence were found to be significantly associated with Cav-1 expression. The median disease-free survival (DFS) of patients with negative Cav-1 expression was significantly better than that of patients with positive Cav-1 expression (not reached vs. 10.2 months, p < 0.001). Moreover, patients with positive Cav-1 expression had a worse median overall survival (OS) compared to patients with negative Cav-1 expression (14.2 vs. 40.3 months, p = 0.004). In the multivariate analysis, Cav-1 expression (positive vs. negative) was an independent prognostic factor for DFS (p < 0.001, hazard ratio (HR) 2.58) and OS (p = 0.031, HR 1.87), as was lymph node metastasis. Conclusion: Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy. Targeting Cav-1 would be a potential option for future gastric cancer treatment.
dc.identifier.citationŞeker, M., Aydın, D., Bilici, A., Yavuzer, D., Özgün Geçer, M., Özçelik, M. ... Aliustaoğlu,M. (2017). Correlation of caveolin-1 expression with prognosis in patients with gastric cancer after gastrectomy. Oncology Research and Treatment, 40(4), 185-190. https://dx.doi.org/10.1159/000456620
dc.identifier.doi10.1159/000456620
dc.identifier.endpage190
dc.identifier.issn2296-5270
dc.identifier.issn2296-5262
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage185
dc.identifier.urihttps://dx.doi.org/10.1159/000456620
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3590
dc.identifier.volume40
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofOncology Research and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCaveolin-1
dc.subjectPrognosis
dc.subjectGastric Cancer
dc.subjectImmunohistochemistry
dc.titleCorrelation of caveolin-1 expression with prognosis in patients with gastric cancer after gastrectomy
dc.typeArticle

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