Can chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapy

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dc.authorid0000-0001-6742-8464
dc.contributor.authorCeylan, Hasan Hüseyin
dc.contributor.authorBilsel, Kerem
dc.contributor.authorBüyükpınarbaşılı, Nur
dc.contributor.authorCeylan, Hamid
dc.contributor.authorErdil, Mehmet
dc.contributor.authorTuncay, İbrahim
dc.contributor.authorŞen, Cengiz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:36Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.descriptionWOS: 000378963600017
dc.descriptionPubMed ID: 27068292
dc.description.abstractBackground: We aimed to investigate the effect of adipose tissue-derived mesenchymal stem cells (ADSCs) on chondral healing using the microfracture (MF) technique. Methods: Thirty male rabbits were randomly divided into three groups. Standard cylindrical osteochondral defects (OCDs) were created in the weight-bearing areas of the medial condyles of all the right knees; the defects were four millimeters in diameter and two millimeters in depth. The control group (group A) was restricted to spontaneous healing. For group B, we performed MF with a 1.5-mm drill. For group C, we applied MF using the same method and then applied 3 x 10(6) ADSCs to the defect area. At eight weeks post-operation, the subjects were sacrificed, and the distal femoral joint surfaces were evaluated histopathologically for chondral healing. The samples were scored according to the International Cartilage Repair Society (ICRS) scale. Results: The results for group C were significantly better than those for group A in terms of the surface properties (p = 0.003). The matrix evaluation was better for group A than for group C (p = 0.01). The cell distribution, cell viability and subchondral bone parameters were similar between the groups (p = 0.198, p = 0.387 and p = 0.699). The cartilage mineralization parameter was better for group C than for group A (p = 0.001). The signs of healing were better for group C than for group B, but the differences were not significant (p = 0.185). Conclusions: Improvements with additional ADSC treatments were not statistically significant in cases in which ADSC treatment was compared with isolated MF treatment.
dc.description.sponsorshipIstanbul Bezmialem Valdf University Scientific Research Projects Department [9.2012/11]en_US
dc.description.sponsorshipThis study was supported by the Istanbul Bezmialem Valdf University Scientific Research Projects Department. Grant number was 9.2012/11. We thank Omer Uysal for the statistical analysis; Fatma Eyuboglu for the cell culture procedure assistance; Safak Sayar, Oznur Inan and Onder Huseyin Bas for the animal laboratory assistance.en_US
dc.identifier.citationCeylan, H. H., Bilsel, K., Büyükpınarbaşılı, N., Ceylan, H., Erdil, M., Tuncay, İ. ... Şen, C. (2016). Can chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapy. Knee, 23(3), 442-449. https://dx.doi.org/10.1016/j.knee.2015.11.008
dc.identifier.doi10.1016/j.knee.2015.11.008
dc.identifier.endpage449
dc.identifier.issn0968-0160
dc.identifier.issn1873-5800
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage442
dc.identifier.urihttps://dx.doi.org/10.1016/j.knee.2015.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3362
dc.identifier.volume23
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofKneeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdipocyte Tissue Derived Stem Cell
dc.subjectOsteochondral Defect
dc.subjectMicrofracture
dc.subjectChondral Healing
dc.subjectCartilage Repair
dc.titleCan chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapy
dc.typeArticle

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