Altered tissue factor activity and disrupted oxidant-antioxidant status in saliva of patients with oral lichen planus

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dc.contributor.authorCansız, Derya
dc.contributor.authorBeler, Merih
dc.contributor.authorÜnal, İsmail
dc.contributor.authorEğilmezer, Gizem
dc.contributor.authorMızrak, Zülal
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2025-06-03T08:59:05Z
dc.date.available2025-06-03T08:59:05Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: The aim of our study was to investigate salivary tissue factor (TF) activity and oxidant-antioxidant status, which is an important defense system, in saliva samples collected from patients with oral lichen planus (OLP), and to determine the relationship between the antioxidant system and TF activity in OLP. Materials and Methods: Saliva samples were collected from patients with OLP (n=20) and healthy subjects (n=13). TF activity, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels, glutathione S-transferase (GST), and superoxide dismutase (SOD) activities were measured. Results: NO levels and GST activities were increased, whereas GSH levels and SOD activities were decreased, when compared with healthy subjects in the saliva samples collected from patients with OLP. In addition, TF activity was increased in the OLP group compared with the control group Conclusion: The results revealed that the salivary oxidant-antioxidant balance was disrupted in parallel with the increase in TF activity in patients with OLP.
dc.identifier.citationCansız, D., Beler, M., Ünal, İ., Eğilmezer, G., Mızrak, Z. ... Emekli Alturfan, E. (2024). Altered tissue factor activity and disrupted oxidant-antioxidant status in saliva of patients with oral lichen planus. Experimed, 14(2), 85-91. http://dx.doi.org/10.26650/experimed.1461284
dc.identifier.doi10.26650/experimed.1461284
dc.identifier.endpage91
dc.identifier.issn2667-5846
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85202775344
dc.identifier.scopusqualityQ4
dc.identifier.startpage85
dc.identifier.urihttp://dx.doi.org/10.26650/experimed.1461284
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12930
dc.identifier.volume14
dc.identifier.wosWOS:001322096300004
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorCansız, Derya
dc.institutionauthorÜnal, İsmail
dc.institutionauthorid0000-0002-6274-801X
dc.institutionauthorid0000-0002-8664-3298
dc.language.isoen
dc.relation.ispartofExperimed
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial 4.0 International License
dc.subjectOral Lichen Planus
dc.subjectOxidative Stress
dc.subjectSaliva
dc.subjectTissue Factor
dc.titleAltered tissue factor activity and disrupted oxidant-antioxidant status in saliva of patients with oral lichen planus
dc.typeArticle

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