Genetic polymorphism in the serotonin transporter gene-linked polymorphic region and response to serotonin reuptake inhibitors in patients with premature ejaculation

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dc.authorid0000-0001-5254-2563
dc.contributor.authorÖzbek, Emin
dc.contributor.authorÖtünçtemur, Alper
dc.contributor.authorŞimşek, Abdulmuttalip
dc.contributor.authorPolat, Emre Can
dc.contributor.authorÖzcan, Levent
dc.contributor.authorKöse, Osman
dc.contributor.authorÇekmen, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:28Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:28Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionWOS: 000346477700001
dc.descriptionPubMed ID: 25518026
dc.description.abstractOBJECTIVES: Serotonin plays a central role in ejaculation and selective serotonin reuptake inhibitors have been successfully used to treat premature ejaculation. Here, we evaluated the relationship between a polymorphism in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the response of patients with premature ejaculation to SSRI medication. METHODS: Sixty-nine premature ejaculation patients were treated with 20 mg/d paroxetine for three months. The Intravaginal Ejaculatory Latency Time and International Index of Erectile Function scores were compared with baseline values. The patients were scored as having responded to therapy when a 2-fold or greater increase was observed in Intravaginal Ejaculatory Latency Time compared with baseline values after three months. Three genotypes of 5-HTTLPR were studied: LL, LS and SS. The appropriateness of the allele frequencies in 5-HTTLPR were analyzed according to Hardy-Weinberg equilibrium using the chi(2)-test. RESULTS: The short (S) allele of 5-HTTLPR was significantly more frequent in responders than in nonresponders (p<0.05). Out of the 69 total PE patients, 41 patients (59%) responded to therapy. There was no significant difference in the International Index of Erectile Function score at the end of therapy between the responder and nonresponder groups. The frequencies of the L allele and S allele were 20% and 39%, respectively, in the responder group (p<0.05). CONCLUSION: We conclude that premature ejaculation patients with the SS genotype respond well to selective serotonin reuptake inhibitor therapy. Further studies with large patient groups are necessary to confirm this conclusion.
dc.identifier.citationÖzbek, E., Ötünçtemur, A., Şimşek, A., Polat, E. C., Özcan, L., Köse, O. ... Çekmen, M. (2014). Genetic polymorphism in the serotonin transporter gene-linked polymorphic region and response to serotonin reuptake inhibitors in patients with premature ejaculation. Clinics, 69(11), 710-713. https://dx.doi.org/10.6061/clinics/2014(11)01
dc.identifier.doi10.6061/clinics/2014(11)01
dc.identifier.endpage713
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.issue11
dc.identifier.scopusqualityQ2
dc.identifier.startpage710
dc.identifier.urihttps://dx.doi.org/10.6061/clinics/2014(11)01
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2223
dc.identifier.volume69
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHospital das Clínicas da Universidade de São Paulo
dc.relation.ispartofClinicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/*
dc.subjectPremature Ejaculation
dc.subjectSerotonin Transporter Gene Promoter
dc.subjectPolymorphism
dc.subjectSelective Serotonin Reuptake Inhibitors
dc.titleGenetic polymorphism in the serotonin transporter gene-linked polymorphic region and response to serotonin reuptake inhibitors in patients with premature ejaculation
dc.typeArticle

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