Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion

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dc.contributor.authorTosuner, Zeynep
dc.contributor.authorTürkmen, İlknur
dc.contributor.authorArıcı, Sema
dc.contributor.authorSönmez, Cavide
dc.contributor.authorTurna, Seval
dc.contributor.authorOnaran, Öykü
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:57Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:57Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000393891700007
dc.descriptionPubMed ID: 28182079
dc.description.abstractAims: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears. Settings and Design: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions. ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) has been considered to have tight association with high grade intraepithelial lesions. Materials and Methods: A total number of 54 SurePath cervical cytology specimens of patients previously interpreted as atypical squamous cells-undetermined significance (ASC-US), atypical squamous cells-cannot exclude high grade squamous intraepithelial lesion (ASC-H), low grade squamous intraepithelial lesion (LSIL), and high grade squamous intraepithelial lesion (HSIL) were included in our study. Results and Conclusions: ProEx C was positive in 14 of HSILs (100%), 3 of 19 LSILs (16%), 2 of 4 ASC-Hs, and none of ASC-USs (0%). The ProEx C test showed very intense nuclear staining in all cytologically abnormal cells. Further studies are indicated to evaluate the diagnostic role of ProEx C.
dc.identifier.citationTosuner, Z., Türkmen, İ., Arıcı, S., Sönmez, C., Turna, S. ve Onaran, Ö. (2017). Immunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion. Journal of Cytology, 34(1), 34-38. https://dx.doi.org/10.4103/0970-9371.197605
dc.identifier.doi10.4103/0970-9371.197605
dc.identifier.endpage38
dc.identifier.issn0970-9371
dc.identifier.issn0974-5165
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage34
dc.identifier.urihttps://dx.doi.org/10.4103/0970-9371.197605
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3080
dc.identifier.volume34
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltd
dc.relation.ispartofJournal of Cytologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectASC-H
dc.subjectASC-US
dc.subjectHSIL
dc.subjectImmunocytochemistry
dc.subjectLSIL
dc.subjectProEx C
dc.titleImmunocytoexpression profile of ProExC in smears interpreted as ASC-US, ASC-H, and cervical intraepithelial lesion
dc.typeArticle

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