Fine mapping of locus Xq25.1-27-2 for a low caries experience phenotype

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dc.contributor.authorKüchler, Erika Calvano
dc.contributor.authorFeng, Ping
dc.contributor.authorDeeley, Kathleen
dc.contributor.authorFitzgerald, Carly A.
dc.contributor.authorMeyer, Chelsea
dc.contributor.authorGorbunov, Anastasia
dc.contributor.authorBezamat, Mariana
dc.contributor.authorReis, Maria Fernanda
dc.contributor.authorNoel, Jacqueline
dc.contributor.authorKouzbari, M. Zahir
dc.contributor.authorGranjeiro, Jose Mauro
dc.contributor.authorAntunes, Leonardo Santos
dc.contributor.authorAntunes, Lívia Azeredo Alves
dc.contributor.authorAbreu, Fernanda Volpe De
dc.contributor.authorMeneghim, Marcelo de Castro
dc.contributor.authorTannure, Patrícia Nivoloni
dc.contributor.authorSeymen, Figen
dc.contributor.authorKoruyucu, Mine
dc.contributor.authorPatır, Aslı
dc.contributor.authorVieira, Alexandre Rezende
dc.date.accessioned2020-06-23T14:05:32Z
dc.date.available2020-06-23T14:05:32Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalı
dc.description.abstractObjective: The purpose of this study was to fine map the locus Xq25.1-27-2 in order to identify genetic contributors involved in low caries experience. Design: Seventy-two families from the Philippines were studied. Caries experience was recorded and genomic DNA extracted from peripheral blood was obtained from all subjects. One hundred and twenty-eight polymorphisms in the locus Xq25.1-27-2, a region that contains 24 genes, were genotyped. Association between caries experience and alleles was tested using the transmission disequilibrium test (TOT). This initial analysis was followed by experiments with DNA samples from 1481 subjects from Pittsburgh, 918 children from Brazil, and 275 children from Turkey in order to follow up the results found in the Filipino families. Chi-square or Fisher's exact tests were used. Sequencing of the coding regions and exon-intron boundaries of MST4 and FGF13 were also performed on 91 women from Pittsburgh. Results: Statistically significant association with low caries experience was found for 11 markers in Xq25.1-27-2 in the Filipino families. One marker was in MST4, another marker was in FGF13, and the remaining markers were in intergenic regions. Haplotype analysis also confirmed these results, but the follow up studies with DNA samples from Pittsburgh, Brazil, and Turkey showed associations for a subset of the 11 markers. No coding mutations were identified by sequencing. Conclusions: Our study failed to conclusively demonstrate that genetic factors in Xq25.1-27-2 contribute to caries experience in multiple populations. (C) 2014 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipNIH/NIDCR Granten_US
dc.identifier.citationKüchler, E. C., Feng, P., Deeley, K., Fitzgerald, C. A., Meyer, C., Gorbunov, A. ... Vieira, A. R. (2014). Fine mapping of locus Xq25.1-27-2 for a low caries experience phenotype. Archives of Oral Biology, 59(5), 479-486. https://dx.doi.org/10.1016/j.archoralbio.2014.02.009
dc.identifier.doi10.1016/j.archoralbio.2014.02.009
dc.identifier.endpage486
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpage479
dc.identifier.urihttps://dx.doi.org/10.1016/j.archoralbio.2014.02.009
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5291
dc.identifier.volume59
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd.
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCaries
dc.subjectGenetics
dc.subjectLinkage Disequilibrium
dc.titleFine mapping of locus Xq25.1-27-2 for a low caries experience phenotype
dc.typeArticle

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