Relation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas

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dc.authorid0000-0001-9433-0307
dc.contributor.authorBaşkan, Özdil
dc.contributor.authorSilav, Gökalp
dc.contributor.authorBölükbaşı, Fatih Han
dc.contributor.authorCanöz, Özlem
dc.contributor.authorGeyik, Serdar
dc.contributor.authorElmacı, İlhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:57Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:57Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000368418500004
dc.descriptionPubMed ID: 26537690
dc.description.abstractObjective: The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and apparent diffusion coefficient (ADC) values of low-grade and atypical/anaplastic (high-grade) meningiomas. Methods: Pre-operative diffusion-weighted imaging and histopathological evaluation of 44 patients with meningiomas were performed retrospectively. Regions of interest (ROIs) were manually drawn on the ADC images. In total six ROI measurements were taken in three consecutive slices, and the average of the mean ADC value was used. The relationship between the ADC and Ki-67 values was investigated, and the ADC values of the low-grade and high-grade meningiomas were compared. Results: 31 (70%) patients had low-grade the meningiomas. 10 (23%) patients had atypical and 3 (7%) had anaplastic meningiomas. ADC values of the low-grade and high-grade meningiomas were 0.81 +/- 0.12 x 10(-3) and 0.66 +/- 0.08 x 10(-3) mm(2) s(-1), respectively. Ki-67 proliferation indexes were 2.19% +/- 1.14% for low-grade and 11.20% 6 9.80% for high-grade meningiomas. A statistically significant negative correlation between Ki-67 proliferation index and ADC values of the low-grade and high-grade meningiomas was detected (r(2) - 0.326, p < 0.001). High-grade meningiomas had lower ADC values than that of low-grade meningiomas. There was statistically significant difference between the ADC values of the lowgrade and high-grade meningiomas (p < 0.001). Conclusion: Our data provide an inverse correlation between the ADC and Ki-67 proliferation index values of meningiomas. ADC values can be used for histopathological characterization of the meningiomas and presurgical planning. Advances in knowledge: The purpose of this study was to investigate the relationship between Ki-67 proliferation indexes and ADC values of low-grade and atypical/ anaplastic (high-grade) meningiomas. In addition, we compared the ADC and Ki-67 proliferative index values of the low-grade and atypical/anaplastic (high-grade) meningiomas. We concluded that there was an inverse correlation between the ADC and Ki-67 proliferation index values in meningiomas, and we have found statistically significant difference between the ADC values of the lowgrade and high-grade meningiomas. ADC values can be used for histopathological characterization of the meningiomas and pre-surgical planning.
dc.identifier.citationBaşkan, Ö., Silav, G., Bölükbaşı, F. H., Canöz, Ö., Geyik, S. ve Elmacı, İ. (2016). Relation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas. British Journal Of Radiology, 89(1057). https://dx.doi.org/10.1259/bjr.20140842
dc.identifier.doi10.1259/bjr.20140842
dc.identifier.issn0007-1285
dc.identifier.issn1748-880X
dc.identifier.issue1057
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1259/bjr.20140842
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2112
dc.identifier.volume89
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBritish Inst Radiology
dc.relation.ispartofBritish Journal Of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApparent Diffusion
dc.subjectKi-67
dc.subjectProliferation Index in Meningiomas
dc.titleRelation of apparent diffusion coefficient with Ki-67 proliferation index in meningiomas
dc.typeArticle

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