The effects of repetitive transcranial magnetic stimulation and aerobic exercise on cognition, balance and functional brain networks in patients with Alzheimer's disease

Basit Öğe Kaydı
dc.authorid0000-0003-0552-8464
dc.authorid0000-0001-5118-4776
dc.authorid0000-0003-4292-5717
dc.contributor.authorBudak, Miray
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2023-09-13T11:11:01Z
dc.date.available2023-09-13T11:11:01Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Fizyoterapi ve Rehabilitasyon Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Ergoterapi Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractThe purpose of this study was to investigate the effects of high-frequency repetitive Transcranial Magnetic Stimulation (rTMS) and aerobic exercises (AE) in addition to the pharmacological therapy (PT) in Alzheimer's Disease (AD). Twenty-seven patients with AD aged >= 60 years were included in the study and divided into 3 groups (rTMS, AE and control). All groups received PT. rTMS group (n = 10) received 20 Hz rTMS over dorsolateral prefrontal cortex (dlPFC) bilaterally and AE group (n = 9) received the structured moderate-intensity AE for 5 consecutive days/week over 2 weeks. Control group (n = 8) only received PT. Cognition, balance, mobility, quality of life (QoL), and resting state functional brain activity were evaluated one week before and one week after the interventions. (ClinicalTrials.gov ID:NCT05102045). Significant improvements were found in executive functions, behavior, and QoL in the rTMS group, in balance and mobility in the AE group, and in the visual memory and behavior in the control group (p < 0.05). Significant differences were found in the behavior in favor of the rTMS group, and balance in favor of the AE group (p < 0.05). There was a significant increase in activation on middle temporal gyrus, intra calcarine, central opercular cortex, superior parietal lobule, and paracingulate cortex in Default Mode Network (DMN) in the rTMS group (p < 0.05). High-frequency rTMS over bilateral dlPFC may improve executive functions and behavior and lead to increased activation in DMN, structured moderate-intensity AE may improve balance and mobility, and PT may improve memory and behaviour compared to pretreatment in AD.
dc.identifier.citationBudak, M., Bayraktaroğlu, Z. ve Hanoğlu, L. (2023). The effects of repetitive transcranial magnetic stimulation and aerobic exercise on cognition, balance and functional brain networks in patients with Alzheimer's disease. Cognitive Neurodynamics, 17(1), 39-61. https://dx.doi.org/10.1007/s11571-022-09818-x
dc.identifier.doi10.1007/s11571-022-09818-x
dc.identifier.endpage61
dc.identifier.issn1871-4080
dc.identifier.issn1871-4099
dc.identifier.issue1
dc.identifier.pmid36704634
dc.identifier.scopus2-s2.0-85131099869
dc.identifier.scopusqualityQ3
dc.identifier.startpage39
dc.identifier.urihttps://dx.doi.org/10.1007/s11571-022-09818-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11422
dc.identifier.volume17
dc.identifier.wos000802894500001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBudak, Miray
dc.institutionauthorBayraktaroğlu, Zübeyir
dc.institutionauthorHanoğlu, Lütfü
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofCognitive Neurodynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAerobic Exercise
dc.subjectAlzheimer's Disease
dc.subjectCognitive Function
dc.subjectFunctional MRI
dc.subjectMagnetic Stimulation
dc.subjectRepetitive Transcranial
dc.subjectResting State Networks
dc.titleThe effects of repetitive transcranial magnetic stimulation and aerobic exercise on cognition, balance and functional brain networks in patients with Alzheimer's disease
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Sağlık Bilimleri Enstitüsü Diğer Yayınlar Koleksiyonu
Daha fazla yükle