The effects of focused ultrasound pulsation of nucleus accumbens in opioid-dependent rats

Basit Öğe Kaydı
dc.authorid0000-0003-2610-1830
dc.authorid0000-0002-6393-1465
dc.contributor.authorDeveci, Erdem
dc.contributor.authorKılıç, Alperen
dc.contributor.authorYılmaz, Onur
dc.contributor.authorNabi, Aynur
dc.contributor.authorErgün, Arif Şanlı
dc.contributor.authorBozkurt, Ayhan Mert
dc.contributor.authorKurtulmuş, Ayşe
dc.contributor.authorÖztürk, Ahmet Kutlu
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorAydın, Mehmet Volkan
dc.contributor.authorŞahan, Ebru
dc.contributor.authorKırpınar, İsmet
dc.date.accessioned2019-12-24T08:01:27Z
dc.date.available2019-12-24T08:01:27Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Deep Brain Stimulation (DBS) is the only modality proven to be effective on selective stimulation of the deep brain structures. It was previously reported that, by using DBS, stimulation of nucleus accumbens (NA), a region that plays a pivotal role in the pathogenesis of substance addiction, is effective for the treatment of substance addiction. Objective: The purpose of the current study was to observe how the morphine-conditioned place preference changed in rats by stimulating NA with a non-invasive method, focused ultrasound (US) and to detect whether there would be any tissue damage caused by US waves. Methods: We used low-intensity focused ultrasound (LIFU), a noninvasive modality, in a place conditioning model to stimulate NA in rats. Results: At the initial stage of our study, we used morphine to induce place preference. As expected, morphine administration caused significant place preference. After the place preference was obtained by morphine, we divided the rats into two groups. One group received LIFU waves to NA and the other group received only sham, that is, no stimulation with US waves. Rats in both groups were continued to receive morphine. Then, we investigated whether LIFU and sham will reduce morphine-induced place preference or not. We observed that morphine-induced place preference had an ongoing raise in the sham group while no raise was detected in the ultrasound group. Although LIFU prevented the rats from the raise, it did not cause a significant reduction of morphine preference. Conclusion: We state that there is a need for future studies to investigate the effects of low-intensity focused ultrasound as an alternative treatment modality in addiction.
dc.identifier.citationDeveci, E., Kılıç, A., Yılmaz, O., Nabi, A., Ergün, A. S., Bozkurt, A. M. ... Kırpınar, İ. (2019). The effects of focused ultrasound pulsation of nucleus accumbens in opioid-dependent rats. Psychiatry and Clinical Psychopharmacology, 29(4), 748-759. https://doi.org/10.1080/24750573.2019.1631942
dc.identifier.doi10.1080/24750573.2019.1631942
dc.identifier.endpage759
dc.identifier.issn2475-0573
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage748
dc.identifier.urihttps://doi.org/10.1080/24750573.2019.1631942
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4638
dc.identifier.volume29
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis
dc.relation.ispartofPsychiatry and Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectMorphine Dependence
dc.subjectLow Intensity Focused Ultrasound
dc.subjectNucleus Accumbens
dc.subjectConditioned Place Preference
dc.subjectDeep Brain Stimulation
dc.titleThe effects of focused ultrasound pulsation of nucleus accumbens in opioid-dependent rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Kılıc, Alperen-2019.pdf
Boyut:
2.91 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu