Impact of valve surgery on serum osteopontin levels in patients with mitral regurgitation

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dc.authorid0000-0001-5825-8627
dc.authorid0000-0002-4607-5724
dc.authorid0000-0001-9975-5507
dc.authorid0000-0003-1919-3183
dc.authorid0000-0002-4281-0867
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorGüler, Gamze Babür
dc.contributor.authorGüler, Ekrem
dc.contributor.authorDemir, Gültekin Günhan
dc.contributor.authorHatipo?lu, Suzan
dc.contributor.authorZehir, Regayip
dc.contributor.authorKızılırmak, Filiz
dc.contributor.authorKaraca, O?uz
dc.contributor.authorEsen, Ali Metin
dc.contributor.authorBarutçu, İrfan
dc.contributor.authorTürkmen, Muhsin
dc.contributor.authorCan, Mehmet Mustafa
dc.contributor.authorSerebruany, Victor
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:59Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:59Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000349515700002
dc.descriptionPubMed ID: 25592683
dc.description.abstractObjective: Osteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurgitation (MR). Methods: Thirty-two patients with severe MR scheduled for surgery were included in the study. Echocardiography markers were assessed preoperatively and at 3 months following the surgery and matched with the serum OPN levels. Results: Valve surgery was associated with a reduction of the ejection fraction (EF) from 55.2 +/- 6.3 to 48.8 +/- 7.1% after surgery, p < 0.001. Following surgery, the OPN level was significantly higher than preoperatively (mean 245, range 36-2,284 ng/ml vs. 76,6-486 ng/ml, p = 0.007). Preoperative OPN exhibited a slight negative correlation with the EF (r = -0.35, p = 0.04), and a moderate correlation with vena contracta (r = -0.38, p = 0.02). There were no other meaningful correlations between conventional echocardiographic parameters and OPN. Conclusion: Following valve surgery due to severe MR, patients exhibited a decrease in EF and an increase in OPN levels. The assessment of preoperative OPN failed to strongly predict probable LV dysfunction. (C) 20155. Karger AG, Basel
dc.identifier.citationGüneş, H. M., Güler, G. B., Güler, E., Demir, G. G., Hatipo?lu, S., Zehir, R. ... Serebruany, V. (2015). Impact of valve surgery on serum osteopontin levels in patients with mitral regurgitation. Cardiology (Switzerland),130(2), 82-86. https://dx.doi.org/10.1159/000368299
dc.identifier.doi10.1159/000368299
dc.identifier.endpage86
dc.identifier.issn0008-6312
dc.identifier.issn1421-9751
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage82
dc.identifier.urihttps://dx.doi.org/10.1159/000368299
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2121
dc.identifier.volume130
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofCardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMitral Regurgitation
dc.subjectOsteopontin
dc.subjectEjection Fraction
dc.subjectValve Surgery
dc.subjectEchocardiography
dc.titleImpact of valve surgery on serum osteopontin levels in patients with mitral regurgitation
dc.typeArticle

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