A comparison of the circulating endocan levels between the inflammatory and malignant diseases of the same organ: The breast

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dc.authorid0000-0002-9452-9276
dc.authorid0000-0002-0141-3515
dc.contributor.authorBasım, Pelin
dc.contributor.authorArğun, Derya
dc.date.accessioned2022-01-03T08:08:56Z
dc.date.available2022-01-03T08:08:56Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose Idiopathic granulomatous mastitis (IGM) is a benign inflammatory breast disease that can clinically mimic breast carcinoma (BC). The aim of this study was to compare the endocan levels between inflammatory and neoplastic diseases of the breast, and to determine whether endocan is a convenient diagnostic biomarker for early stage BC and for the differentiation from IGM. Material and methods A total of 65 patients, consisting of 35 newly diagnosed with BC and 30 with IGM proven by core biopsies, and 20 healthy volunteer women with similar demographic characteristics were enrolled in the study. Endocan was assayed by a commercially available enzyme-linked immunosorbent assay kit. Results The endocan level was found to be significantly higher in the BC group than in the control group (p = 0.003). Although the endocan level was higher in the IGM group compared to the control group, there was no statistically significant difference (p = 0.057). No significant distinctive difference was observed between the BC and IGM groups in terms of the endocan level (p = 0.373). The serum endocan level was found to be positively correlated with BMI and vitamin D levels in the BC group (p = 0.043 andp = 0.023, respectively). Conclusions We demonstrated that the serum endocan level was increased in patients with BC compared to healthy subjects, whereas in our enrolled study patient population, endocan was not a statistically valid biomarker for the differential diagnosis between BC and IGM. These findings indicate the potential role of endocan in the pathogenesis of BC.
dc.identifier.citationBasım, P. ve Arğun, D. (2021). A comparison of the circulating endocan levels between the inflammatory and malignant diseases of the same organ: The breast. Journal of Investigative Surgery, 34(11), 1207-1213. https://doi.org/10.1080/08941939.2020.1792008
dc.identifier.doi10.1080/08941939.2020.1792008
dc.identifier.endpage1213
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue11
dc.identifier.scopusqualityQ3
dc.identifier.startpage1207
dc.identifier.urihttps://doi.org/10.1080/08941939.2020.1792008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8747
dc.identifier.volume34
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBreast Cancer
dc.subjectBiomarker
dc.subjectDifferential Diagnosis
dc.subjectEndocan
dc.subjectIdiopathic Granulomatous Mastitis
dc.subjectInflammation
dc.subjectTumorogenesis
dc.titleA comparison of the circulating endocan levels between the inflammatory and malignant diseases of the same organ: The breast
dc.typeArticle

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