Gene-environment interaction in molar-incisor hypomineralization

Basit Öğe Kaydı
dc.authorid0000-0002-8440-367X
dc.contributor.authorBezamat, Mariana
dc.contributor.authorSouza, Juliana Feltrin de
dc.contributor.authorSilva, Fernanda M.F.
dc.contributor.authorCorrêa, Emilly G.
dc.contributor.authorFatturi, Aluhê Lopes
dc.contributor.authorBrancher, Joäo Armando
dc.contributor.authorCarvalho, Flávia M.
dc.contributor.authorCavallari, Tayla
dc.contributor.authorBertolazo, Laís
dc.contributor.authorMachado-Souza, Cleber
dc.contributor.authorKoruyucu, Mine
dc.contributor.authorBayram, Merve
dc.contributor.authorRacic, Andrea
dc.contributor.authorHarrison, Benjamin M.
dc.contributor.authorSweat, Yan Yan
dc.contributor.authorLetra, Ariadne
dc.contributor.authorStuden-Pavlovich, Deborah A.
dc.contributor.authorSeymen, Figen
dc.contributor.authorAmendt, Brad A.
dc.contributor.authorIani Werneck, Renata
dc.contributor.authorCosta, Marcelo C.
dc.contributor.authorModesto, Adriana M.
dc.contributor.authorVieira, Alexandre Rezende
dc.date.accessioned2021-01-29T08:02:29Z
dc.date.available2021-01-29T08:02:29Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalı
dc.description.abstractMolar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the disease. During head and neck development, the interferon regulatory factor 6 (IRF6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (TGFA) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. In this present study, it was hypothesized that these genes interact and contribute to predisposition of MIH. Environmental factors affecting children that were 3 years of age or older were also hypothesized to play a role in the disease etiology. Those factors included respiratory issues, malnutrition, food intolerance, infection of any sort and medication intake. A total of 1,065 salivary samples from four different cohorts were obtained, and DNA was extracted from each sample and genotyped for nine different single nucleotide polymorphisms. Association tests and logistic regression implemented in PLINK were used for analyses. A potential interaction between TGFA rs930655 with all markers tested in the cohort from Turkey was identified. These interactions were not identified in the remaining cohorts. Associations (p<0.05) between the use of medication after three years of age and MIH were also found, suggesting that conditions acquired at the age children start to socialize might contribute to the development of MIH.
dc.description.sponsorshipCarlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ)en_US
dc.description.sponsorshipCAPESen_US
dc.description.sponsorshipUniversity of Pittsburgh School of Dental Medicine Dean's Summer Research programen_US
dc.description.sponsorshipFundacao Araucariaen_US
dc.identifier.citationBezamat, M., Souza, J. F., Silva, F. M.F., Corrêa, E. G., Fatturi, A. L., Brancher, J. A. ... Vieira, A. R. (2021). Gene-environment interaction in molar-incisor hypomineralization. PLOS One, 16(1). https://dx.doi.org/10.1371/journal.pone.0241898
dc.identifier.doi10.1371/journal.pone.0241898
dc.identifier.issn1932-6203
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1371/journal.pone.0241898
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6449
dc.identifier.volume16
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.ispartofPLOS Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectMolar Incisor Hypomineralization (MIH)
dc.subjectInteraction
dc.subjectChildren
dc.titleGene-environment interaction in molar-incisor hypomineralization
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Bayram-Merve-2021.pdf
Boyut:
1.09 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diş Hekimliği Fakültesi Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu