Clinical and demographic features of hidradenitis suppurativa: A multicentre study of 1221 patients with an analysis of risk factors associated with disease severity

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dc.authorid0000-0002-7022-913X
dc.authorid0000-0002-4119-9939
dc.contributor.authorÖzkur, Ezgi
dc.contributor.authorKaradağ, Ayşe Serap
dc.contributor.authorÜstüner, P.
dc.contributor.authorAksoy, Bülent
dc.contributor.authorEsme, Pelin
dc.contributor.authorÇalışkan, E.
dc.contributor.authorAkoğlu, Gülşen
dc.contributor.authorKalkan, Gülhan
dc.contributor.authorDemirseren, Duriye Deniz
dc.contributor.authorPolat, Mualla
dc.contributor.authorÖzden, Müge Güler
dc.contributor.authorKılınç, Fadime
dc.contributor.authorYalçınkaya İyidal, Ayşegül
dc.contributor.authorKıvanç Altunay, İlknur
dc.contributor.authorTürkmen, Meltem
dc.contributor.authorUğurer, Ece
dc.contributor.authorBaysak, Sevim
dc.contributor.authorFettahlıoğlu Karaman, Bilge
dc.contributor.authorMammadli, Kifayat
dc.contributor.authorBaykal Selçuk, Leyla
dc.contributor.authorTürkoğlu, Zülal
dc.contributor.authorAtçı, Tolgahan
dc.contributor.authorDidar Balcı, Didem
dc.contributor.authorÖzsoy Adışen, Esra
dc.contributor.authorTemel, Berkay
dc.contributor.authorAktan, Serhat
dc.contributor.authorGelincik Kaçar, Nida
dc.contributor.authorGündüz, Kamer
dc.contributor.authorTürel Ermertcan, Aylin
dc.contributor.authorÖzdemir, Mustafa
dc.contributor.authorÜnal Çakıter, Alkım
dc.contributor.authorÇölgeçen, Emine
dc.contributor.authorUçmak, Derya
dc.contributor.authorKelekçi, Handan Kıymet
dc.contributor.authorAtaseven, Arzu
dc.contributor.authorDurmaz, Koray
dc.contributor.authorKaya Özden, Hatice
dc.contributor.authorEngin, Berat
dc.contributor.authorÖzbek Yazıcı, Sercan
dc.contributor.authorAlpsoy, Erkan
dc.date.accessioned2021-10-11T07:30:54Z
dc.date.available2021-10-11T07:30:54Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.description.abstractBackground Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results The mean age of disease onset was 26.2 +/- 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 +/- 8.4 years with a delay in diagnosis of 5.8 +/- 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity.
dc.identifier.citationÖzkur, E., Karadağ, A. S., Üstüner, P., Aksoy, B., Esme, P., Çalışkan, E. ... Alpsoy, E. (2021). Clinical and demographic features of hidradenitis suppurativa: A multicentre study of 1221 patients with an analysis of risk factors associated with disease severity. Clinical and Experimental Dermatology, 46(3), 532-540. https://dx.doi.org/10.1111/ced.14478
dc.identifier.doi10.1111/ced.14478
dc.identifier.endpage540
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage532
dc.identifier.urihttps://dx.doi.org/10.1111/ced.14478
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8408
dc.identifier.volume46
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject1221 Patients
dc.subjectHidradenitis Suppurativa
dc.subjectDemographic Features
dc.subjectDermatology
dc.titleClinical and demographic features of hidradenitis suppurativa: A multicentre study of 1221 patients with an analysis of risk factors associated with disease severity
dc.typeArticle

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