Utility of diffusion-weighted MRI to detect changes in liver diffusion in benign and malignant distal bile duct obstruction: The influence of choice of b-values

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dc.contributor.authorKaran, Belgin
dc.contributor.authorErbay, Gürcan
dc.contributor.authorKoç, Zafer
dc.contributor.authorPourbagher, Ayşin
dc.contributor.authorYıldırım, Sedat
dc.contributor.authorAğıldere, Ahmet Muhteşem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:57Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:57Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.descriptionWOS: 000388250400013
dc.descriptionPubMed ID: 27592163
dc.description.abstractPurpose: The study sought to evaluate the potential of diffusion-weighted magnetic resonance imaging to detect changes in liver diffusion in benign and malignant distal bile duct obstruction and to investigate the effect of the choice of b-values on apparent diffusion coefficient (ADC). Methods: Diffusion-weighted imaging was acquired with b-values of 200, 600, 800, and 1000 s/mm(2). ADC values were obtained in 4 segments of the liver. The mean ADC values of 16 patients with malignant distal bile duct obstruction, 14 patients with benign distal bile duct obstruction, and a control group of 16 healthy patients were compared. Results: Mean ADC values for 4 liver segments were lower in the malignant obstruction group than in the benign obstruction and control groups using b = 200 s/mm(2) (P < .05). Mean ADC values of the left lobe medial and lateral segments were lower in the malignant obstruction group than in the benign obstructive and control groups using b = 600 s/mm2 (P < .05). Mean ADC values of the right lobe posterior segment were lower in the malignant and benign obstruction groups than in the control group using b = 1000 s/mm(2) (P < .05). Using b = 800 s/mm(2), ADC values of all 4 liver segments in each group were not significantly different (P > .05). There were no correlations between the ADC values of liver segments and liver function tests. Conclusion: Measurement of ADC shows good potential for detecting changes in liver diffusion in patients with distal bile duct obstruction. Calculated ADC values were affected by the choice of b-values.
dc.identifier.citationKaran, B., Erbay, G., Koç, Z., Pourbagher, A., Yıldırım, S. ve Ağıldere, A. M. (2016). Utility of diffusion-weighted MRI to detect changes in liver diffusion in benign and malignant distal bile duct obstruction: The influence of choice of b-values. Canadian Association of Radiologists Journal, 67(4), 395-401. https://dx.doi.org/10.1016/j.carj.2016.03.006
dc.identifier.doi10.1016/j.carj.2016.03.006
dc.identifier.endpage401
dc.identifier.issn0846-5371
dc.identifier.issn1488-2361
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage395
dc.identifier.urihttps://dx.doi.org/10.1016/j.carj.2016.03.006
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2114
dc.identifier.volume67
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofCanadian Association of Radiologists Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiliary Obstruction
dc.subjectDiffusion-Weighted Imaging
dc.subjectLiver Fibrosis
dc.subjectMagnetic Resonance Imaging
dc.subjectB-Value
dc.titleUtility of diffusion-weighted MRI to detect changes in liver diffusion in benign and malignant distal bile duct obstruction: The influence of choice of b-values
dc.typeArticle

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