Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study

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dc.authorid0000-0003-0804-1475
dc.contributor.authorSürmen, Mustafa Gani
dc.contributor.authorSürmen, Saime
dc.contributor.authorCansız, Derya
dc.contributor.authorÜnal, İsmail
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorBüyükkayhan, Derya
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2022-12-16T11:11:34Z
dc.date.available2022-12-16T11:11:34Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractRotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), is the principal fatty acid of medium-chain triglycerides in ketogenic diets. Beneficial effects of ketogenic diets were shown in PD. We applied proteomic methods to reveal the effects of octanoic acid in rotenone toxicity in zebrafish to gain information on the use of ketogenic diets in PD. Zebrafish were exposed to 5 mu g/ml rotenone and octanoic acid (20 and 60 mg/ml) for 30 days. LC-MS/MS analysis was performed. Raw files were analyzed by Proteome Discoverer 2.4 software, peptide lists were searched against Danio rerio proteins. STRING database was used for protein annotations or interactions. 2317 unique proteins were quantified, 302 proteins were differentially expressed. Proteins involved in cell organization, biogenesis, transport, response to stimulus were most frequently expressed. Our study is first to report that the alterations in the expressions of proteins related to energy and redox system, stress response, and cytoskeleton proteins caused by rotenone exposure were normalized by octanoic acid treatment in zebrafish.
dc.description.sponsorshipScientific Research Projects Coordination Unit of University of Health Sciencesen_US
dc.identifier.citationSürmen, M. G., Sürmen, S., Cansız, D., Ünal, İ., Üstündağ, Ü. V., Alturfan, A. A. ... Emekli Alturfan, E. (2022). Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study. Journal of Biochemical and Molecular Toxicology, 36(5). https://doi.org/10.1002/jbt.23024
dc.identifier.doi10.1002/jbt.23024
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue5
dc.identifier.pmid35218269
dc.identifier.scopus2-s2.0-85125266893
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.23024
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10140
dc.identifier.volume36
dc.identifier.wos000761236500001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCansız, Derya
dc.institutionauthorÜstündağ, Ünsal Veli
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMass Spectrometry
dc.subjectOctanoic Acid
dc.subjectParallel Reaction Monitoring
dc.subjectProteomics
dc.subjectRotenone
dc.subjectZebrafish
dc.titleAmelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study
dc.typeArticle

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