Diagnostic approach of tuberculous lymphadenitis in a multicenter study

dc.contributor.authorYenilmez, Ercan
dc.contributor.authorÖzakınsel, Duygu
dc.contributor.authorKöse, Adem
dc.contributor.authorOlçar, Yıldız
dc.contributor.authorDuman, Zehra
dc.contributor.authorCeylan, Mehmet R.
dc.contributor.authorBozkurt, Fatma
dc.contributor.authorAltunal, Lütfiye Nilsun
dc.contributor.authorGezer, Yakup
dc.contributor.authorAsan, Ali
dc.contributor.authorGöktaş, Sibel Y.
dc.contributor.authorKöşger, Sümeyye
dc.contributor.authorMert, Kamil
dc.contributor.authorSeyman, Derya
dc.contributor.authorEmre, Salih
dc.contributor.authorKaraa?aç, Leman
dc.contributor.authorParlak, Emine
dc.contributor.authorÜnlü, Gülten
dc.contributor.authorYıldız, İlknur E.
dc.contributor.authorİnce, Nevin
dc.contributor.authorKaya, Şafak
dc.contributor.authorYalçı, Aysun
dc.contributor.authorHamidi, Aziz A.
dc.contributor.authorEkinci, Semiha Ç.
dc.contributor.authorTural, Ersin
dc.contributor.authorMert, Ali
dc.contributor.authorKöse, Şükran
dc.date.accessioned2024-06-28T07:59:18Z
dc.date.available2024-06-28T07:59:18Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Tuberculous lymphadenitis (TBLN) is the most common infectious etiology of peripheral lymphadenopathy in adults, in Turkiye. This study aimed to identify the demographic, clinical, and laboratory variables that differentiate TBLN from non-tuberculous lymphadenitis (NTBLN), as well as the etiology of lymphadenopathy in adults. Methodology: Patients who were over 18 years old and were referred to the infectious disease outpatient clinics with complaints of swollen peripheral lymph nodes, and who underwent lymph node biopsy between 1 January 2010 and 1 March 2021, were included in this multicenter, nested case-control study. Results: A total of 812 patients at 17 tertiary teaching and research hospitals in Turkiye were included in the study. TBLN was the most frequent diagnosis (53.69%). The proportion of patients diagnosed with TBLN was higher among females; and among those who had a higher erythrocyte sedimentation rate, positive purified protein derivative test, and positive interferon-gamma release test result (p < 0.05). However, TBLN was less frequent among patients with generalized lymphadenopathy, bilateral lymphadenopathy, axillary lymphadenopathy, inguinal lymphadenopathy, hepatomegaly, splenomegaly, leukocytosis, and moderately increased C reactive protein levels (p < 0.05). Conclusions: Identifying the variables that predict TBLN or discriminate TBLN from NTBLN will help clinicians establish optimal clinical strategies for the diagnosis of adult lymphadenopathy.
dc.identifier.citationYenilmez, E., Özakınsel, D., Köse, A., Olçar, Y., Duman, Z., Ceylan, M. R. ... Köse, Ş. (2024). Diagnostic approach of tuberculous lymphadenitis in a multicenter study. Journal of Infection in Developing Countries, 18(5), 742-750. http://dx.doi.org/10.3855/jidc.19502
dc.identifier.doi10.3855/jidc.19502
dc.identifier.endpage750
dc.identifier.issn2036-6590
dc.identifier.issue5
dc.identifier.pmid38865395
dc.identifier.scopus2-s2.0-85195861479
dc.identifier.scopusqualityQ3
dc.identifier.startpage742
dc.identifier.urihttp://dx.doi.org/10.3855/jidc.19502
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12666
dc.identifier.volume18
dc.identifier.wos001247147800013en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMert, Ali
dc.language.isoen
dc.relation.ispartofJournal of Infection in Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAdult
dc.subjectEtiology
dc.subjectLymph Node Biopsy
dc.subjectLymphadenopathy
dc.subjectTuberculous Lymphadenitis
dc.subjectTurkey
dc.titleDiagnostic approach of tuberculous lymphadenitis in a multicenter study
dc.typeArticle

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