The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer

Basit Öğe Kaydı
dc.contributor.authorCoşkunpınar, Ender
dc.contributor.authorAkkaya, Nergiz
dc.contributor.authorYıldız, Pınar
dc.contributor.authorMüşteri Oltulu, Yasemin
dc.contributor.authorAynacı, Engin
dc.contributor.authorİşbir, Turgay
dc.contributor.authorYaylım, İlhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:30Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:30Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/Aim: Heat-shock proteins (HSPs) are molecular chaperones which modify the structures and interactions of other proteins. The aim of our study was to investigate HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Ninety-seven patients with NSCLC and 97 healthy controls were included in the study. Real-time polymerase chain reaction was used for genotyping. Results: The frequency of mutant CC genotype for HSP90AA1 (rs4947C/T), mutant AA genotype for HSP90AB1 (rs13296A/G) and mutant CC genotype for HSP90B1 (rs2070908 C/G) was significantly higher in the patient group than in controls (p=0.019, p=0.004 and p=0.036, respectively). The frequency of patients with homozygote mutant allele was also significantly higher than that of controls and possessing of the mutant genotype increased the risk for disease by approximately 2.9, 4.8, 1.9 for HSP90AA1, HSP90AB1 and HSP90B1, respectively. The present study appears to be the first of its kind to report data on these gene polymorphisms in patients with NSCLC in the Turkish population.
dc.description.sponsorshipIstanbul Universityen_US
dc.identifier.citationCoşkunpınar, E., Akkaya, N., Yıldız, P., Müşteri Oltulu, Y., Aynacı, E., İşbir, T. ... Yaylım, İ. (2014). The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer. Anticancer Research, 34(2), 753-758.
dc.identifier.endpage757
dc.identifier.issn0250-7005
dc.identifier.issn1791-7530
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage753
dc.identifier.urihttps://hdl.handle.net/20.500.12511/810
dc.identifier.volume34
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInternational Institute of Anticancer Research
dc.relation.ispartofAnticancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHSP90AA1
dc.subjectHSP90AB1
dc.subjectHSP90B1
dc.subjectNSCLC
dc.subjectSNPs
dc.subjectTurkish Population
dc.titleThe significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
aynaci-engin(2014).pdf
Boyut:
62.82 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu