Analysis of the involvement of the thyroid gland using computed tomography in patients with suspected SARS-CoV-2 infection: A retrospective study

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dc.authorid0000-0002-8440-367X
dc.authorid0000-0001-8945-2385
dc.contributor.authorAkkoyunlu, Yasemin
dc.contributor.authorKalaycıoğlu, Bora
dc.contributor.authorYurtsever, İsmail
dc.contributor.authorEren, Abdulkadir
dc.contributor.authorBayram, Merve
dc.contributor.authorMert, Ali
dc.contributor.authorAkkoyunlu, Muhammed Emin
dc.date.accessioned2021-07-02T09:39:45Z
dc.date.available2021-07-02T09:39:45Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: SARS-CoV-2 primarily infects the respiratory tract and leads to severe pneumonia by binding to the ACE-2 receptor. The virus can also interact with ACE-2 receptors expressed in other tissues as in thyroid. This study predicted the complications involving the thyroid in patients with suspected SA RS-CoV-2. PATIENTS AND METHODS: Patients with suspected SARS-CoV-2 infection between March 11, 2020-May 31, 2020 were retrospectively evaluated. Sixty-nine patients who were radiologically diagnosed as COVID-19 according to thoracic CT and had previously performed thoracic CT before November 2019 were included in the study according to the exclusion and inclusion criteria. Age and gender-matched controls (No. 69) were selected with normal thoracic CT whose PCR tests were also negative. Thyroid densities of participants were calculated and compared from the previous and current thoracic CTs. Results were also compared with the control group. RESULTS: Participants were composed of 69 patients (39 male, mean age 64.35 years). Thyroid densities were significantly decreased from 89HU to 76HU for whole gland, from 88HU to 76HU for right lobes and from 87.5HU to 75.5HU for left lobes at current thoracic CTs performed during COVID-19 (p<0.001, p<0.001, p<0.001 respectively). The decrease in densities of the whole thyroid gland. both left and right lobes. was correlated with mortality (p<0.001). The changes in thyroid densities were not correlated with age nor gender. The decreases in HU values of thyroid densities for whole gland, left and right lobes, were correlated with mortality (p<0.001, p<0.001. and p<0.001 respectively). CONCLUSIONS: COVID-19 is a multi-systemic disease that threatens vital organs, including the thyroid. Future studies are needed to investigate the association between SARS-CoV-2 and other complications.
dc.identifier.citationAkkoyunlu, Y., Kalaycıoğlu, B., Yurtsever, İ., Eren, A., Bayram, M., Mert, A. ... Akkoyunlu, M. E. (2021). Analysis of the involvement of the thyroid gland using computed tomography in patients with suspected SARS-CoV-2 infection: A retrospective study. European Review for Medical and Pharmacological Sciences, 25(11), 4149-4155. https://dx.doi.org/10.26355/eurrev_202106_26058
dc.identifier.doi10.26355/eurrev_202106_26058
dc.identifier.endpage4155
dc.identifier.issn1128-3602
dc.identifier.issue11
dc.identifier.scopusqualityQ2
dc.identifier.startpage4149
dc.identifier.urihttps://dx.doi.org/10.26355/eurrev_202106_26058
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7433
dc.identifier.volume25
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Editore s.r.l
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSARS-CoV-2
dc.subjectThyroid
dc.subjectComputed Tomography
dc.subjectCOVID-19
dc.titleAnalysis of the involvement of the thyroid gland using computed tomography in patients with suspected SARS-CoV-2 infection: A retrospective study
dc.typeArticle

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