Histologic and biomechanical evaluation of the effects of social stress and the antidepressant fluoxetine on tendon healing in rats

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dc.contributor.authorÖztürk, Muhammed Beşir
dc.contributor.authorEgemen, Onur
dc.contributor.authorBasat, Salih Onur
dc.contributor.authorBozdağ, Ergün
dc.contributor.authorSakız, Damlanur
dc.contributor.authorAkan, Mithat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:13Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.descriptionWOS: 000410008900010
dc.descriptionPubMed ID: 26578832
dc.description.abstractImpaired wound healing in humans under psychological stress and the positive effects of antidepressant drugs on wound healing were also shown in the literature. However, there are currently no studies regarding the effects of antidepressant drugs on tendon healing. The aim of this study was to compare tendon healing under normal conditions versus social stress. We also aimed to perform a histological and biomechanical analysis of the effects of the antidepressant drug fluoxetine on tendon healing. Sixty Sprague Dawley rats were divided into six groups. A social stress regimen was used to stress the rats. The use of fluoxetine in the social stress group yielded significantly better biomechanical results and the collagen organizations of the fluoxetine group were more similar to the normal tendon collagen organization. Fluoxetine seems to inhibit the negative effects of stress on tendon healing and seems to improve tendon healing.
dc.identifier.citationÖztürk, M. B., Egemen, O., Basat, S. O., Bozdağ, E., Sakız, D. ve Akan, M. (2015). Histologic and biomechanical evaluation of the effects of social stress and the antidepressant fluoxetine on tendon healing in rats. Journal of Hand and Microsurgey, 7(2), 294-299. https://dx.doi.org/10.1007/s12593-015-0204-4
dc.identifier.doi10.1007/s12593-015-0204-4
dc.identifier.endpage299
dc.identifier.issn0974-3227
dc.identifier.issn0974-6897
dc.identifier.issue2
dc.identifier.startpage294
dc.identifier.urihttps://dx.doi.org/10.1007/s12593-015-0204-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3130
dc.identifier.volume7
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag
dc.relation.ispartofJournal of Hand and Microsurgeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSocial Stress
dc.subjectFluoxetine
dc.subjectTendonhealing
dc.subjectSocial Stress and Tendon Healing
dc.subjectSSRI and Tendon Healing
dc.titleHistologic and biomechanical evaluation of the effects of social stress and the antidepressant fluoxetine on tendon healing in rats
dc.typeArticle

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