Exploring the relationship between dietary phytochemical index and chemotherapy-related symptoms: insights from a cross-sectional study

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dc.contributor.authorYüksel, Barış
dc.contributor.authorDumlu Bilgin, Gözde
dc.contributor.authorKavsara, Hasan Kaan
dc.date.accessioned2025-11-11T10:50:56Z
dc.date.available2025-11-11T10:50:56Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Beslenme ve Diyetetik Ana Bilim Dalı
dc.description.abstractPhytochemicals may confer substantial benefits in alleviating chemotherapy-related symptoms. This cross-sectional study aimed to determine the role of dietary phytochemicals on treatment-related symptoms in patients receiving chemotherapy. Data including demographic variables, anthropometric measures such as weight and height, 3-day food record, and Nightingale Symptom Assessment Scale (N-SAS), a composite measure of patients' chemotherapy-related symptoms, were gathered via face-to-face interviews. The dietary phytochemical index (DPI) was computed based on the patient's food records and presented by dividing into quartiles. The study included 152 participants with a mean age of 59.59 ± 13.19 years. The mean N-SAS score was 2.16 ± 0.80. The average DPI score for the entire group was 24.66 ± 6.55, significantly higher in women (26.61 ± 6.06) than men (23.05 ± 6.54) (p = 0.001). As the DPI quartile values increased, there was a statistically significant decrease in N-SAS scores (p = 0.002). A significantly negative correlation was found between the N-SAS score and DPI, as well as all cancers (r = −0.364; p < 0.001). Additionally, a negative correlation was observed between the N-SAS score and specific cancer types, comprising lung cancer (r = −0.513; p = 0.005), breast cancer (r = −0.612; p < 0.001), and gastrointestinal system (GIS) cancer (r = −0.329; p = 0.033). Increasing dietary phytochemicals in chemotherapy patients may help manage treatment-related symptoms. Phytochemicals may confer substantial benefits in alleviating chemotherapy-related symptoms. This cross-sectional study aimed to determine the role of dietary phytochemicals on cancer-related symptoms in patients receiving chemotherapy. A significantly negative correlation was found between N-SAS score and DPI and all cancers (r = −0.364; p < 0.001) and different cancer types such as lung (r = −0.513; p = 0.005), breast (r = −0.612; p < 0.001), and GIS (r = −0.329; p = 0.033). As a result, increasing dietary phytochemicals in chemotherapy patients may help manage treatment-related symptoms.
dc.identifier.citationYüksel, B., Dumlu Bilgin, G. ve Kavsara, H. K. (2024). Exploring the relationship between dietary phytochemical index and chemotherapy-related symptoms: insights from a cross-sectional study. Food Science and Nutrition, 12(12), 10306-10314. http://dx.doi.org/10.1002/fsn3.4568
dc.identifier.doi10.1002/fsn3.4568
dc.identifier.endpage10314
dc.identifier.issn2048-7177
dc.identifier.issue12
dc.identifier.pmid39723091
dc.identifier.scopus2-s2.0-85208537936
dc.identifier.scopusqualityQ1
dc.identifier.startpage10306
dc.identifier.urihttp://dx.doi.org/10.1002/fsn3.4568
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13189
dc.identifier.volume12
dc.identifier.wosWOS:001355365800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKavsara, Hasan Kaan
dc.institutionauthorid0000-0002-0322-0397
dc.language.isoen
dc.relation.ispartofFood Science and Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCancer
dc.subjectChemotherapy
dc.subjectDietary Phytochemical Index
dc.subjectSymptoms
dc.titleExploring the relationship between dietary phytochemical index and chemotherapy-related symptoms: insights from a cross-sectional study
dc.typeArticle

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