Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib

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dc.authorid0000-0002-8814-7351
dc.authorid0000-0001-7369-0426
dc.contributor.authorYerlikaya, Azmi
dc.contributor.authorOkur, Emrah
dc.contributor.authorBaykal, Ahmet Tarık
dc.contributor.authorAcılan, Ceyda
dc.contributor.authorBoyacı, İhsan
dc.contributor.authorUlukaya, Engin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:18Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:18Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThis data article contains data related to the research article entitled, "A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line" by Yerlikaya et al. [1]. The research article presented 2-DE and nLC-MS/MS based proteomic analysis of proteasome inhibitor bortezomib-induced changes in the expression of cellular proteins. The report showed that GRP78 and TCEB2 were over-expressed in response to treatment with bortezomib for 24. h. In addition, the report demonstrated that Hsp70, the 26S proteasome non-ATPase regulatory subunit 14 and sequestosome 1 were increased at least 2 fold in p53-deficient 4T1 cells. The data here show for the first time the increased expressions of Card10, Dffb, Traf3 and Trp53bp2 in response to inhibition of the 26S proteasome. The information presented here also shows that both Traf1 and Xiap (a member of IAPs) are also downregulated simultaneously upon proteasomal inhibition. The increases in the level of Card10 and Trp53bp2 proteins were verified by Western blot analysis in response to varying concentrations of bortezomib for 24. h.
dc.identifier.citationYerlikaya, A., Okur, E., Baykal, A. T., Acılan, C., Boyacı, İ. ve Ulukaya, E. (2014). Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib. Data in Brief, 1, 56-59. https://dx.doi.org/10.1016/j.dib.2014.09.003
dc.identifier.doi10.1016/j.dib.2014.09.003
dc.identifier.endpage59
dc.identifier.issn2352-3409
dc.identifier.scopusqualityN/A
dc.identifier.startpage56
dc.identifier.urihttps://dx.doi.org/10.1016/j.dib.2014.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1374
dc.identifier.volume1
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofData in Briefen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subjectProteomic Analysis
dc.subjectp53-Independent
dc.subjectApoptosis
dc.subjectBortezomib
dc.titleData for a proteomic analysis of p53-independent induction of apoptosis by bortezomib
dc.typeArticle

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