520 nm and 660 nm light-emitting diodes modulates pancreatic development and beta cell functions in zebrafish embryos

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dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorÜnal, İsmail
dc.contributor.authorCansız, Derya
dc.contributor.authorBeler, Merih
dc.contributor.authorKanagaraj, Naveen Krishna
dc.contributor.authorKumar, Amrish Rajendra
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2025-12-02T12:03:23Z
dc.date.available2025-12-02T12:03:23Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractGreen and Red LEDs increase insulin production, but their comparative effects on pancreatic and beta cell development are unclear. Zebrafish embryos were divided into three groups: Control (n = 60), Green (G) (n = 60), and Red (R) (n = 60), then irradiated for three days (14 hours/day) with 0.5 W/cm2 G (λpeak = 520 nm, 180 mA) and R (λpeak = 660 nm, 210 mA). At the end of 72 h, pancreatic and beta cells, circadian rhythm, and oxidative stress gene were analyzed using RT-PCR. Malondialdehyde, nitric oxide, superoxide dismutase, and glutathione levels were also evaluated. In the Red group, pancreatic area increased by ~97.13% compared to the Control group and by approximately ~62.16% compared to the G group (both p < 0.0001), and no significant difference in beta cell area (p = 0.964). G group insulin expression increased 2.31-fold compared to R group (p < 0.0001). Red LED treatment increased MDA levels (p < 0.001), oxidative stress (fth1b, nqo1) (p < 0.0001), and per1b during the photophase (p < 0.0001) compared to G group. R LED treatment increases oxidative stress and disrupts circadian rhythm, leading to reduced insulin secretion. The positive effects of G LED treatment have potential for metabolic syndrome, diabetes, and pancreatic diseases.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) ; Scientific Research Projects Foundation (BAP) of the Marmara University
dc.identifier.citationÜstündağ, Ü. V., Ünal, İ., Cansız, D., Beler, M., Kanagaraj, N. K., Kumar, A. R. ... Emekli Alturfan, E. (2025). 520 nm and 660 nm light-emitting diodes modulates pancreatic development and beta cell functions in zebrafish embryos. Photochemistry and Photobiology, 101(5), 1327-1342. http://dx.doi.org/10.1111/php.14050
dc.identifier.doi10.1111/php.14050
dc.identifier.endpage1342
dc.identifier.issn0031-8655
dc.identifier.issn1751-1097
dc.identifier.issue5
dc.identifier.pmid39655413
dc.identifier.scopus2-s2.0-85211317554
dc.identifier.scopusqualityQ1
dc.identifier.startpage1327
dc.identifier.urihttp://dx.doi.org/10.1111/php.14050
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13266
dc.identifier.volume101
dc.identifier.wosWOS:001375361100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnal, İsmail
dc.institutionauthorCansız, Derya
dc.institutionauthorid0000-0002-8664-3298
dc.institutionauthorid0000-0002-6274-801X
dc.language.isoen
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/TDK/2021/10172
dc.relation.ispartofPhotochemistry and Photobiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBeta Cell
dc.subjectInsulin
dc.subjectLight Emitting Diode
dc.subjectPancreas
dc.subjectZebrafish
dc.title520 nm and 660 nm light-emitting diodes modulates pancreatic development and beta cell functions in zebrafish embryos
dc.typeArticle

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