Current state of image-guided focal therapy for prostate cancer

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dc.authorid0000-0002-5009-8435
dc.contributor.authorTourinho-Barbosa, Rafael Rocha
dc.contributor.authorWood, Bradford J.
dc.contributor.authorAbreu, Andre Luis
dc.contributor.authorNahar, Bruno
dc.contributor.authorShin, Toshitaka
dc.contributor.authorGüven, Selçuk
dc.contributor.authorPolascik, Thomas J.
dc.date.accessioned2021-04-06T11:05:15Z
dc.date.available2021-04-06T11:05:15Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose To review the current evidence regarding protocols and outcomes of image-guided focal therapy (FT) for prostate cancer (PCa). Methods A literature search of the latest published studies assessing primary FT for PCa was carried out in Medline and Cochrane library databases followed by a critical review. FT modalities, follow-up strategies, and oncological and toxicity outcomes were summarized and discussed in this review. Results Twenty-four studies with six different sources of energy met the inclusion criteria. A heterogeneity of patient selection, energy sources, treatment templates, and definitions of failure was found among the studies. While a third of patients may be found to have additional cancer burden over 3-5 years following FT, most patients will remain free of a radical procedure. The vast majority of patients maintain urinary continence and good erectile function after FT. Acute urinary retention is the most common complication, whilst severe complications remain rare. Conclusion An increasing number of prospective studies with longer follow-up have been recently published. Acceptable cancer control and low treatment toxicity after FT have been consistently reported. Follow-up imaging and routine biopsy must be encouraged post-FT. While there is no reliable PSA threshold to predict failure after FT, reporting post-FT positive biopsies and retreatment rates appear to be standard when assessing treatment efficacy.
dc.identifier.citationTourinho-Barbosa, R. R., Wood, B. J., Abreu, A. L., Nahar, B., Shin, T., Güven, S. ... Polascik, T. J. (2021). Current state of image-guided focal therapy for prostate cancer. World Journal of Urology, 39(3), 701-717. https://dx.doi.org/10.1007/s00345-020-03254-4
dc.identifier.doi10.1007/s00345-020-03254-4
dc.identifier.endpage717
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage701
dc.identifier.urihttps://dx.doi.org/10.1007/s00345-020-03254-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6703
dc.identifier.volume39
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofWorld Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectProstate Cancer
dc.subjectAblation Techniques
dc.subjectFocal Therapy
dc.subjectLocalized
dc.subjectOutcome
dc.titleCurrent state of image-guided focal therapy for prostate cancer
dc.typeArticle

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