Enhancing memory capacity by experimentally slowing theta frequency oscillations using combined EEG-tACS

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dc.authorid0000-0002-7555-3801
dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.contributor.authorAktürk, Tuba
dc.contributor.authorde Graaf, Tom A.
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorSack, Alexander T.
dc.date.accessioned2022-09-02T07:42:59Z
dc.date.available2022-09-02T07:42:59Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstracthe coupling of gamma oscillation (similar to 40+ Hz) amplitude to the phase of ongoing theta (similar to 6 Hz) oscillations has been proposed to be directly relevant for memory performance. Current theories suggest that memory capacity scales with number of gamma cycles that can be fitted into the preferred phase of a theta cycle. Following this logic, transcranial alternating current stimulation (tACS) may be used to adjust theta cycles (increasing/decreasing theta frequency) to decrease or increase memory performance during stimulation. Here, we used individualized EEG-informed theta tACS to (1) experimentally "slow down" individual theta frequency (ITF), (2) evaluate cognitive after effects on a battery of memory and learning tasks, and (3) link the cognitive performance changes to tACS-induced effects on theta-band oscillations as measured by post EEG. We found frequencyand task-specific tACS after effects demonstrating a specific enhancement in memory capacity. This tACS-induced cognitive enhancement was specific to the visual memory task performed immediately after tACS offset, and specific to the ITF-1 Hz (slowing) stimulation condition and thus following a protocol specifically designed to slow down theta frequency to enhance memory capacity. Follow-up correlation analyses in this group linked the enhanced memory performance to increased left frontalparietal theta-band connectivity. Interestingly, resting-state theta power immediately after tACS offset revealed a theta power increase not for the ITF-1 Hz group, but only for the ITF group where the tACS frequency was 'optimal' for entrainment. These results suggest that while individually calibrated tACS at peak frequency maximally modulates resting-state oscillatory power, tACS stimulation slightly below this optimal peak theta frequency is better suited to enhance memory capacity performance. Importantly, our results further suggest that such cognitive enhancement effects can last beyond the period of stimulation and are linked to increased network connectivity, opening the door towards more clinical and applied relevance of using tACS in cognitive rehabilitation and/or neurocognitive enhancement.
dc.identifier.citationAktürk, T., de Graaf, T. A., Güntekin, B., Hanoğlu, L. ve Sack, A. T. (2022). Enhancing memory capacity by experimentally slowing theta frequency oscillations using combined EEG-tACS. Scientifc Reports, 12(1). https://doi.org/10.1038/s41598-022-18665-z
dc.identifier.doi10.1038/s41598-022-18665-z
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid35987918
dc.identifier.scopus2-s2.0-85137009071
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-022-18665-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9675
dc.identifier.volume12
dc.identifier.wos000843446300035en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAktürk, Tuba
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorHanoğlu, Lütfü
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAlternating-Current Stimulation
dc.subjectHigh-Resolution Eeg
dc.subjectWorking-Memory
dc.subjectSubsequent Memory
dc.titleEnhancing memory capacity by experimentally slowing theta frequency oscillations using combined EEG-tACS
dc.typeArticle

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