COVID-19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group

Basit Öğe Kaydı
dc.authorid0000-0002-0476-5452
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorHazar, Volkan
dc.contributor.authorMalbora, Barış
dc.contributor.authorKüpesiz, Alphan
dc.contributor.authorAygüneş, Utku
dc.contributor.authorFışgın, Tunç
dc.contributor.authorKarakükçü, Musa
dc.contributor.authorKuşkonmaz, Barış
dc.contributor.authorÇakı Kılıç, Suar
dc.contributor.authorBayırlı, Derya
dc.contributor.authorArman Bilir, Özlem
dc.contributor.authorYalçın, Koray
dc.contributor.authorGözmen, Salih
dc.contributor.authorUygun, Vedat
dc.contributor.authorElli, Murat
dc.contributor.authorSarbay, Hakan
dc.contributor.authorKüpesiz, Funda Tayfun
dc.contributor.authorŞaşmaz, Hatice İlgen
dc.contributor.authorAdaklı Aksoy, Başak
dc.contributor.authorYılmaz, Ebru
dc.contributor.authorOkur, Fatma Visal
dc.contributor.authorTekkeşin, Funda
dc.contributor.authorDemir Yenigürbüz, Fatma
dc.contributor.authorÖzek, Gülcihan
dc.contributor.authorAtay, Abdullah Avni
dc.contributor.authorOk Bozkaya, İkbal
dc.contributor.authorÇelen, Suna
dc.contributor.authorÖztürkmen, Seda
dc.contributor.authorGüneş, Adalet Meral
dc.contributor.authorGürsel, Orhan
dc.contributor.authorGüler, Elif
dc.contributor.authorÖzcan, Alper
dc.contributor.authorUçkan Çetinkaya, Duygu
dc.contributor.authorAydoğdu, Selime
dc.contributor.authorÖzbek, Namık Yaşar
dc.contributor.authorKarasu, Gülsün
dc.contributor.authorSezgin, Gülay
dc.contributor.authorDoğru, Ömer
dc.contributor.authorAlbayrak, Davut
dc.contributor.authorÖztürk, Gülyüz
dc.contributor.authorAksoylar, Serap
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorOdaman Al, Işık
dc.contributor.authorSezgin Evim, Melike
dc.contributor.authorAkbayram, Sinan
dc.contributor.authorÖncül, Yurday
dc.contributor.authorZengin, Emine
dc.contributor.authorAlbayrak, Canan
dc.contributor.authorTimur, Çetin
dc.contributor.authorDüzenli Kar, Yeter
dc.contributor.authorÇakmaklı, Hasan Fatih
dc.contributor.authorTüfekçi, Özlem
dc.contributor.authorTöret, Ersin
dc.contributor.authorAntmen, Bülent
dc.date.accessioned2024-05-27T11:48:03Z
dc.date.available2024-05-27T11:48:03Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. Objectives: The study aimed to analyze the clinical signs, risk factors, and outcomes for ICU admission and mortality in a large pediatric cohort who underwent allogeneic HSCT prior to COVID-19 infection. Method: In this nationwide study, we retrospectively reviewed the data of 184 pediatric HSCT recipients who had COVID-19 between March 2020 and August 2022. Results: The median time from HSCT to COVID-19 infection was 209.0 days (IQR, 111.7–340.8; range, 0–3845 days). The most common clinical manifestation was fever (58.7%). While most patients (78.8%) had asymptomatic/mild disease, the disease severity was moderate in 9.2% and severe and critical in 4.4% and 7.6%, respectively. The overall mortality was 10.9% (n: 20). Deaths were attributable to COVID-19 in nine (4.9%) patients. Multivariate analysis revealed that lower respiratory tract disease (LRTD) (OR, 23.20, p:.001) and lymphopenia at diagnosis (OR, 5.21, p:.006) were risk factors for ICU admission and that HSCT from a mismatched donor (OR, 54.04, p:.028), multisystem inflammatory syndrome in children (MIS-C) (OR, 31.07, p:.003), and LRTD (OR, 10.11, p:.035) were associated with a higher risk for COVID-19-related mortality. Conclusion: While COVID-19 is mostly asymptomatic or mild in pediatric transplant recipients, it can cause ICU admission in those with LRTD or lymphopenia at diagnosis and may be more fatal in those who are transplanted from a mismatched donor and those who develop MIS-C or LRTD.
dc.description.sponsorshipAmerican Journal Experts.en_US
dc.identifier.citationBozkurt, C., Hazar, V., Malbora, B., Küpesiz, A., Aygüneş, U., Fışgın, T. ... Antmen, B. (2024). COVID-19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group. Pediatric Transplantation, 28(3). http://dx.doi.org/10.1111/petr.14758
dc.identifier.doi10.1111/petr.14758
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue3
dc.identifier.pmid38659218
dc.identifier.scopus2-s2.0-85191193300
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1111/petr.14758
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12511
dc.identifier.volume28
dc.identifier.wos001207499700001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorElli, Murat
dc.institutionauthorOdaman Al, Işık
dc.language.isoen
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdolescents
dc.subjectChildren
dc.subjectCOVID-19
dc.subjectHematopoietic Stem Cell Transplantation
dc.titleCOVID-19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Elli-Murat-2024.pdf
Boyut:
537.35 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu